The Center for Translational Genomic Phenotyping

描述（由申请人提供）：加州大学（UC）戴维斯转化基因组表型中心（CTGP）：国家癌症研究所-人类癌症小鼠模型联盟（NCI-MMHCC）科学领导应用程序将提供集中的发现驱动的体内和离体表型，以验证模型病理学。这主要集中在癌症生物学，但影响预防干预，实验治疗和癌症易感性项目以及。该应用程序分为五个部分。1. 作为研究总结，PI博士Robert Cardiff是过去和新提交的几个MMHCC研究项目的Co-Pl， Co-I和合作者。他与Lewis Chodosh、Cory Abate-Shen和Robert Schreiber共同参与了“目标1”的研究申请。他一直在MMHCC联盟中提供咨询和领导，涉及表型，将小鼠的病理发现转化为人类疾病，并定义和宣传诊断，分期和分级标准，这些标准对于在癌症生物学，预防和实验治疗中使用小鼠模型至关重要。2. 领导计划将A)在预防干预和癌症生物学的特定研究集群中以电子方式协调nci - mmhcc内部项目，并期望促进与这些研究集群相关的u01获奖者之间的合作；B)促进整个MMHCC以及与其他NCI网络和联盟的合作，以划定促进集群合作的研究资源或试点项目；C)通过caELMIR管理和增强现有的NCI癌症模型生物信息学基础设施，包括体内和离体图像的集成图像档案，这些图像档案可以准确地映射到相关的人类生物信息学系统。3. 沟通和协调将通过信息学工具实现，将MMHCC研究附属机构与基因组病理学学院的专家病理学/表型资源联系起来。该小组由国内大多数领先权威和最有经验的小鼠模型和比较病理学家组成。4. 外展将通过专题讨论会和研讨会，以及在加州大学戴维斯分校中心开放的访问实习生/访问教授计划来实现。此外，加州大学戴维斯分校与突变小鼠区域资源中心和敲除小鼠项目存储库的联系为小鼠建模社区提供了额外的扩展。5. 我们在加州大学戴维斯分校的团队开发了MMHCC和NCI的临床前模型信息学。研究已经在加州大学戴维斯分校启动，具体的试点项目设计需要精确的综合数据，包括小鼠群体管理、病理实验室信息系统、整个幻灯片图像、放射学图像数据和显示，以及使用caELMIR、caMOD和caBIG基础设施的电子“实验室笔记本”。这个应用程序与程序的优先级是唯一相关的。这是一个以表型和病理学为中心的领导力U01，得到了许多国家小鼠病理学专家的广泛支持，以及为MMHCC联盟的目的而独特设计的信息学开发的广泛背景和初步工作

DESCRIPTION (provided by applicant): The University of California (UC), Davis Center for Translational Genomic Phenotyping (CTGP): A National Cancer Institute-Mouse Models of Human Cancer Consortium (NCI-MMHCC) Science Leadership Application will provide centralized discovery-driven in-vivo and ex-vivo phenotyping for validation of model pathology. This is predominantly centered on Cancer Biology, but Impacts Preventative Interventions, Experimental Therapeutics and Cancer Susceptibility programs as well. The application is organized in five sections. 1. As a Summary of the Research, the PI, Dr. Robert Cardiff, is a Co-Pl, Co-I and collaborator on several past and newly submitted MMHCC research projects. He Is Co-l on "Goal 1" research applications submitted with Lewis Chodosh, Cory Abate-Shen, and Robert Schreiber. He has consistently provided consultation and leadership within the MMHCC Consortium with respect to phenotypes, translation of pathologic findings in the mouse to the human disease, and defining and publicizing criteria for diagnosis, staging and grading critical to the use of the mouse models in cancer biology, prevention, and experimental therapeutics. 2. The Leadership Plan will A) electronically coordinate intra-NCI-MMHCC projects in the specific research clusters of Preventative Interventions and Cancer Biology and anticipate fostering collaborations among the U0l awardees who are affiliated with these research clusters; B) foster collaborations throughout the MMHCC and with other NCI networks and consortia to delineate research resources or pilot projects that promote the cluster collaborations; and C) manage and enhance the existing NCI cancer model bioinformatics infrastructure through caELMIR with Integrated image archives of in-vivo and ex-vivo images that are accurately mapped to relevant human bioinformatics systems in collaboration. 3. The Communication and Coordination will be achieved through the informatics tools connecting the MMHCC research affiliates with the expert pathology/phenotyping resource embodied In the Academy for Genomic Pathology. This group constitutes most of the leading authorities and most experienced mouse model and comparative pathologists in the country. 4. Outreach will be achieved through symposia and workshops, as well as an open visiting trainee/ visiting professor program at the UC Davis center. In addition, the connections at UC Davis to the Mutant Mouse Regional Resource Center, and the Knockout Mouse Project Repository provide added outreach to the mouse modeling community. 5. Pre-Clinical Models Informatics for the MMHCC and the NCI has been developed, in part, by our group at UC Davis. Studies have been Initiated at UC Davis, and specific pilot projects designs demanding accurate integrated data from mouse colony management, pathology laboratory information systems, whole slide images, radiology image data and display and electronic "lab notebooks" using caELMIR, caMOD, and the caBIG infrastructure. This application is uniquely relevant to the program priorities. This is a Leadership U01 centered on phenotyping and pathology, with extensive support from a host of national experts In mouse pathology, and extensive background and preliminary work In development of Informatics uniquely designed to the purposes of the MMHCC consortium