Bioinformatics/Biostatistics Core

生物信息学/生物统计学核心的目标是满足耶鲁大学孢子在皮肤癌项目和核心中的统计和生物信息学分析需求。另一个主要目标是维护和扩展孢子数据管理和分析系统，用于跟踪生物标本和处理临床和实验数据。生物信息学/生物统计核心的最终目标是提供符合孢子数据和资源共享计划的数据。生物信息学/生物统计学核心的具体目标是目标1：维护和扩展孢子数据管理和分析系统(DMAS)，用于样本跟踪，以及存储和分析所有孢子项目的临床和实验数据，以及目标2：孢子项目数据的生物信息学和统计分析。对于目标1，我们将维护和扩展孢子DMA，该系统目前跟踪caTIssue的孢子标本，使用caArray存储组学数据，并使用CalnIntegrator进行数据整合和传播。核心还维护一个专门的数据仓库，用于跨组学模式的综合数据分析。DMAS将紧密集成到孢子标本资源核心中，服务于孢子项目成员的数据管理需求。DMAS将广泛利用耶鲁大学现有的信息学系统和现有的caBIG技术。核心将强调与更广泛的皮肤癌社区的互动。对于目标2，生物信息学/生物统计核心将解决孢子项目产生的分析问题。核心提供的服务范围从规划活动到具体分析问题的咨询。更具体地说，核心将安排与孢子调查人员的定期会议，并对任何生物信息学/生物统计学问题保持开放政策。由于观察到的数据可能具有与假设不同的特征，核心将定期进行中期分析，动态更新功率计算，根据需要开发新的统计和生物信息学方法，向孢子调查人员提供及时的建议，从而在整个研究中发挥重要作用。

The goal of the Bioinformatics/Biostatistics core is to address the statistical and bioinformatics analysis needs of the Yale SPORE in skin cancer projects and cores. Another major goal is the maintenance and extension of a SPORE Data Management and Analysis System (DMAS) for tracking of biological specimens and processing of clinical and experimental data. A final goal of the Bioinformatics/Biostatistics Core is the provision of data compliant with the SPORE data and resource-sharing plan. The specific aims of the Bioinformatics/Biostatistics Core are Aim 1: Maintenance and extension of a SPORE Data Management and Analysis System (DMAS) for specimen tracking, as well as storing and analyzing clinical and experimental data for all SPORE projects, and Aim 2: Bioinformatics and statistical analysis of SPORE project data. For Aim 1, we will maintain and extend the SPORE DMAS, which currently tracks SPORE specimens in caTissue, uses caArray for storing omics data and calntegrator for data integration and dissemination. The Core also maintains a dedicated data warehouse for integrative data analysis across omics modalities. DMAS will be tightly integrated Into the SPORE specimen resource core, and will serve the data management needs of the SPORE project members. DMAS will make extensive use of existing informatics systems at Yale University and existing caBIG technology. The Core will emphasis the Interactions with the wider skin cancer community. For Aim 2, the Bioinformatics/Biostatistics Core will address the analytic questions arising from the SPORE projects. Service provided by the Core will range from planning activities to consulting on specific analytic questions. More specifically, the Core will schedule regular meetings with the SPORE investigators, and maintain an open door policy for any bioinformatics/biostatistical questions. Since the observed data can have characteristics different from hypothesized, the Core will conduct regular interim analyses, dynamically update the power calculations, develop new statistical and bioinformatics methodology as needed, provide timely suggestions to SPORE investigators, and thus play an important role in the entire study.