Administrative Core

为了运作一个有凝聚力、协调和有效的项目，项目的临床、研究、技术、数据库/统计和报告组成部分需要中央协调。项目的行政核心提供了项目核心和研究项目的组织结构和整合。另一个对成功至关重要的管理职能是与其他研究项目的联系，这是项目项目成功所依赖的。在本项目中，所有受试者将从匹兹堡阿尔茨海默病研究中心（ADRC）或匹兹堡大学银杏记忆评估研究（GEMS）项目中招募。该项目管理核心将与ADRC的管理核心对接，ADRC目前已成立25年，是一个大型且运作顺利的临床和基础研究实体。ADRC的组织结构作为我们组织项目管理核心的模板，并且免费使用部分ADRC资源极大地促进了项目的运营。该项目的项目负责人Klunk博士是ADRC的联席主任，而ADRC的主任Lopez博士是该项目的项目负责人，这一事实极大地促进了这种互动。此外，Leslie Dunn担任ADRC和本项目的总管理员，在过去的10年里，她一直是ADRC关于GEMS拨款的联络人。本项目的管理与ADRC和GEMS的联系将优化本项目的受试者招募和保留。具体目标是：1)监督项目的所有职能；2)项目预算的管理，包括根据项目优先级的支出和资金分配；3)监督遵守联邦和大学政策和程序，如NIH公共访问政策，数据共享计划和人类受试者研究合规；4)对项目数据库的运行进行行政监督；5)与匹兹堡大学神经内科阿尔茨海默病研究中心（ADRC）联络；6)与匹兹堡大学流行病学学系银杏记忆评价研究（GEMS）工作人员联络。

To operate a cohesive, coordinated and effective Program Project, the clinical, research, technology, database/statistics and reporting components of the program require central coordination. The Administrative Core of the Program Project provides the organizational structure and integration of the Program Project Cores and research projects. Another administrative function critical for success is liaison with other research programs on which the Program Project relies for success. In the case of this Program Project, all subjects will be recruited from either the Pittsburgh Alzheimer's Disease Research Center (ADRC) or the University of Pittsburgh Gingko Evaluation of Memory Study (GEMS) program. The Program Project Administrative Core will interface with the Administrative Core of the ADRC, which is now in its 25th year and is a large and smoothly functioning clinical and basic research entity. The ADRC organizational structure serves as a template for our organization of the Program Project administrative core, and use of some ADRC resources at no cost to the Program Project greatly leverages the Program Project operations. Greatly facilitating this interaction is the fact that the PI of this Program Project, Dr. Klunk, is co-Director of the ADRC and the Director of the ADRC, Dr. Lopez, is a Project Leader on this Program Project. Furthermore, Leslie Dunn serves as overall Administrator for both the ADRC and this Program Project and she has been ADRC liaison on the GEMS grant over the past 10 years. The connections of the administration of this Program Project to the ADRC and GEMS will optimize the recruitment and retention of subjects into this Program Project. The specific aims are: 1) Supervision of all Program Project functions; 2) Management of the Program Project budget, including expenditures and allocation of funds according to Program Project priorities; 3) Monitor compliance with Federal and University policies and procedures, such as NIH Public Access Policy, Data Sharing Plan and Human Subjects Research compliance; 4) Administrative oversight of the functioning of the Program Project Database; 5) Liaison with the University of Pittsburgh Alzheimer's Disease Research Center (ADRC) in the Department of Neurology; and 6) Liaison with the University of Pittsburgh Gingko Evaluation of Memory Study (GEMS) staff in the Department of Epidemiology.