2012 International Meeting on the Molecular Biology of Hepatitis B Viruses

项目说明(申请人提供)：项目摘要本建议是为资助年轻科学家出席2012年国际乙肝病毒分子生物学会议的旅费而提出的申请。2012年23日至26日，牛津大学考试学校和基督教会学院，英国牛津。这次会议是聚集关注乙肝病毒(乙肝病毒)和密切相关的丁型肝炎病毒(HDV)的国际研究人员的唯一论坛。世界上大约25%的人口感染了乙肝病毒。不幸的是，尽管有预防性疫苗可用，但全球范围内仍有许多新感染病例发生，主要是由于成本和其他问题导致疫苗未得到充分利用。此外，对于大约3.6亿已经慢性感染乙肝病毒的人(其中大约1500万人同时感染HDV)来说，疫苗没有治疗价值。因此，全世界每年有50万至100万人死于乙肝病毒/HDV。因此，当务之急是继续基础研究和研究HBVHDV的人员之间的科学交流，而一年一度的乙肝会议就是进行这一交流的场所。2012年会议将坚持和加强传统的形式和交流，在9次口头科学会议、2次海报会议以及较少安排的“联网”时间中进行互动和对话。这次会议的一个特别焦点将是病毒与宿主的相互作用，特别强调细胞生物学、抗病毒免疫和新的治疗靶点。这将由三个基调来促进 地址和一个特别研讨会。与以往一样，已作出巨大努力将会议费用降至最低。此外，自2005年以来，乙肝基金会一直致力于支持这次会议，为会议的组织提供永久的住所，并提供工作人员来组织和宣传会议，特别是 有大量代表不足的少数族裔的大学。为了让初级和少数族裔调查人员参与，NIH提供了支持，以帮助支付会议费用 要求支付初级科学家的费用。 公共卫生相关性：项目简介2012年乙肝病毒分子生物学会议是自1985年以来连续举行的年度系列会议中的下一次预定会议。这是唯一一次将来自世界各地的乙肝病毒(乙肝)和丁型肝炎病毒(HDV)领域的基础科学家聚集在一起的决定性会议。乙肝病毒仍然是全球和美国的主要公共卫生问题，全世界有超过3.6亿人慢性感染，每年高达100万人死于由乙肝病毒和乙肝病毒/HDV引起的肝功能衰竭、肝硬变和肝细胞癌。这次会议是一个重要的、国际公认的平台，可以继续交流关于乙肝病毒和丁型肝炎病毒感染的基础研究方面的信息。

DESCRIPTION (provided by applicant): Project Summary This proposal is a request for funding to support the travel expenses for young scientists to attend and participate in the 2012 International Meeting on the Molecular Biology of Hepatitis B Viruses, scheduled for Sept. 23 - 26, 2012 at the University of Oxford Examination Schools and Christ Church College, Oxford, UK. This meeting is the only forum that gathers the international community of researchers that focus on the hepatitis B virus (HBV) and the closely associated hepatitis delta virus (HDV). Approximately 25% of the world's population has been infected by HBV. Unfortunately, despite the availability of prophylactic vaccines, many new infections occur worldwide, mostly because of underutilization of the vaccine due to cost and other issues. Moreover, for the approximately 360 million people already chronically infected with HBV (approximately 15 million of whom are co-infected with HDV), the vaccine is of no therapeutic value. As a result, between 0.5 and 1 million people die of HBV/HDV every year worldwide. It is therefore imperative that basic research and the scientific exchange among those studying HBV/HDV continue, and the annual HBV meeting represents the venue at which this can occur. The 2012 meeting will uphold and enhance the traditional format and exchange with interaction and dialogue presented in 9 oral scientific sessions, 2 poster sessions as well as less structured "networking" time. A special focus of this meeting will be on virus-host interactions, with a particular emphasis on cell biology, antiviral immunity, and new therapeutic targets. This will be facilitated by three keynote addresses and a special workshop. As in the past, great effort has been made to minimize the cost of the meeting. Furthermore, the Hepatitis B Foundation has made a strong commitment to support this meeting since 2005, in terms of providing a permanent home for organizing the meeting and making its staff available for organizing the meeting and publicizing it, especially to universities with large numbers of underrepresented minorities. In order to allow the participation of junior and minority investigators, support from the NIH to help defray the meeting costs of junior scientists is requested. PUBLIC HEALTH RELEVANCE: Project Narrative The 2012 Molecular Biology of Hepatitis B Viruses Meeting is the next scheduled meeting in an annual series that has been held continuously since 1985. This is the only definitive meeting that brings together basic scientists in the field of hepatitis B virus (HBV) and hepatitis D virus (HDV) from throughout the world. HBV continues to be a major global and US public health problem with more than 360 million individuals chronically infected worldwide and with an annual rate of up to one million deaths due to HBV and HBV/HDV-induced liver failure, cirrhosis, and hepatocellular carcinoma. The meeting is a critical and internationally well recognized platform for continued exchange of information in basic research on HBV and HDV infections.