PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evide

描述（由申请人提供）：PPTOX III是将于2012年5月14日至16日在法国巴黎举行的国际会议。它将侧重于环境暴露和营养在发展过程中对以后生活中的疾病/功能障碍的作用。会议的目标是（1）检查支持这一假设的动物和人类数据（疾病的发育基础），以审查文献的现状并确定影响的机制;（2）确定研究差距和挑战;（3）整合 基础科学和应用科学;（4）影响科学政策。由于这是同类会议中唯一一个完全专注于发展规划整合两个领域（环境化学品暴露和规划以及改变营养和规划）的会议，其独特的结构为领先的研究人员，学生和博士后研究员提供了参加和参与会议的独特机会。因此，它很可能对该领域本身以及开发更综合的疾病预防方法产生巨大影响。即将举行的会议将在其早期范围的基础上，突出新的，当前的问题，如糖尿病/肥胖，免疫功能障碍，癌症和生殖疾病/功能障碍的发展基础，这些都与美国和全球有关。PPTOX III还将涵盖表观遗传学，基因表达，代谢组学和新的方法学成就，以及确定新的研究差距和挑战，并整合基础和应用科学。为了培养年轻的研究人员，口头报告和海报会议已经创建和设计，以突出研究生和博士后研究员的研究。因此，青年与会者的人数取决于会议收到的资金水平。旅行奖有助于抵消经济负担，否则可能会阻止学生和博士后研究员出席和参加会议。申请书还要求提供资金，以部分支付应邀发言者的旅费。为发言者提供两晚住宿和往返会议的旅费。有必要为演讲者提供差旅费，他们为维持这一世界级会议提供必要的想法。会议上代表的独特研究主题和翻译机会不仅对国家儿童健康和人类发展研究所（NICHD）感兴趣，而且对国家癌症研究所（NCI），国家过敏和传染病研究所（NIAID），国家老龄化研究所（NIA），国家心脏病研究所，肺和血液研究所（NHLBI）和国家环境健康科学研究所（NIEHS）。 公共卫生相关性：拟议的会议旨在提出关于发展规划和疾病结果的前线和最新数据，以激发实验和流行病学研究人员和临床医生之间关于毒物和营养素对发展规划的影响的讨论和合作，为学生和博士后提供一个论坛，以学习和亲自与该领域的专家互动，确定研究差距和需求，最后就该领域的现状及其对人类健康的影响达成共识，这将影响欧盟、美国和地球仪的政策。

DESCRIPTION (provided by applicant): PPTOX III is an international conference to be held May 14-16, 2012 in Paris, France. It will focus on the role of environmental exposures and nutrients during development on subsequent diseases/dysfunctions later in life. The goals of the conference are (1) to examine the animal and human data supporting this hypothesis (developmental basis of disease) in order to review the current state of the literature and to identify mechanisms for the effects; (2) to identify research gaps and challenges; (3) to integrate the basic and applied science; and (4) to impact science policy. As this is the only conference of its kind focused entirely on developmental programming integrating two fields (environmental chemical exposures and programming and altered nutrition and programming), it's unique structure offers leading researchers, students and postdoctoral fellows, to mention a few, a distinctive opportunity to attend and participate in the conference. Therefore, it is likely to hav a huge impact on the field itself and the development of a more integrated approach to disease prevention. The forthcoming conference will build on its earlier scope highlighting new, current issues such as the developmental basis of diabetes/obesity, immune dysfunction, cancer, and reproductive diseases/dysfunctions which are pertinent to the U.S. and globally. PPTOX III will also cover epigenetics, gene expression, metabolomics, and new methodological achievements as well as identifying new research gaps and challenges and integrating basic and applied science. To foster young researchers, oral presentation and poster sessions have been created and designed to highlight the research of graduate students and postdoctoral fellows. As such, the number of young participants relies upon the level of funding the conference receives. Travel Awards assist in offsetting the financial burden that might otherwise prevent students and postdoctoral fellows from attending and participating in conferences. The application also requests funds to partially defray travel costs for invited speakers. Speakers are provided lodging for two nights and travel expenses to and from the conference. It is necessary to assist with travel expenses for speakers, who provide cross-fertilization of ideas necessary for sustaining this world class conference. The distinct research topics and translational opportunities represented at the conference will be of interest not only to the National Institute f Child Health and Human Development (NICHD), but National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Aging (NIA), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Environmental Health Sciences (NIEHS) as well. PUBLIC HEALTH RELEVANCE: The proposed conference seeks to present front-line and up-to-date data on developmental programming and disease outcomes, to stimulate discussions and collaborations among and between experimental and epidemiological researchers and clinicians in regard to the influence of toxicants and nutrients on developmental programming, to provide a forum for students and postdoctorals to learn from and interact personally with experts in the fields, to define research gaps and needs, and finally to develop a consensus statement of where the field is and its impact on human health that will impact policy in the European Union, the USA and across the globe.