Training Grant in Clinical Pharmacology

描述（由申请人提供）：本提案请求继续资助美国国立卫生研究院在梅奥诊所-梅奥诊所医学院-梅奥医学院资助的临床药理学奖学金培训计划。这一研究培训经验被整合在一个广泛的课程中，使受训者接触到临床药理学基础科学的关键方面——所有这些都在一个支持的、指导的环境中。临床药理学是一门“桥梁学科”，致力于研究人与药物之间的相互作用。在生物医学科学领域正在发生的“革命”的背景下，一场有望改变医疗实践的革命，临床药理学是分子药理学、基因组学、蛋白质组学、生物信息学和理性治疗学等学科的融合，其最终目标是科学地“个性化”药物治疗。因此，临床药理学旨在增强我们对药物反应的分子基础的理解，并将这些信息应用于翻译界面，从而使药物治疗能够针对潜在的疾病过程和每个患者的独特特征进行定制。然而，我们利用这一独特机会的能力将要求我们在科学上培养新一代的临床药理学家，这是基于“新生物学”提供的基础。大型、全面、综合的学术医疗中心，如梅奥诊所，是培养新一代临床药理学家的理想场所。梅奥之所以能够做到这一点，是因为它将基础医学研究和临床医学研究结合在一起的悠久历史，因为它对临床药理学学科做出贡献的悠久传统，因为梅奥临床药理学培训项目在成功招募和培训内科科学家方面拥有数十年的经验，还因为梅奥一直专注于转化科学。梅奥临床药理学奖学金培训计划将继续强调以实验室为基础的研究培训，系统的临床科学接触和结构化的指导-目标是使每位研究员成为临床药理学的未来领导者。

DESCRIPTION (provided by applicant): This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Clinic-Mayo Clinic College of Medicine-Mayo Medical School. This research training experience is integrated within a broad curriculum that exposes Trainees to critical aspects of the science underlying Clinical Pharmacology ~ all within a supportive, mentoring environment. Clinical Pharmacology represents a "bridge discipline" that is devoted to the study of the interaction between humans and drugs. Within the context of the ongoing" revolution" that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of the disciplines of molecular pharmacology, genomics, proteomics, bioinformatics and rational therapeutics - with an ultimate goal of scientifically "individualized" drug therapy. Therefore, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and to apply that information at the translational interface to make it possible to tailor drug therapy to both the underlying disease process and the unique characteristics of each individual patient. However, our ability to take advantage of this unique opportunity will require that we train a new generation of Clinical Pharmacologists in science that is based on a foundation provided by the "new biology". Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of integrating basic and clinical medical research, because of a long tradition of contributing to the discipline of Clinical Pharmacology, because the Mayo Clinical Pharmacology Training Program has had decades of experience in successfully recruiting and training physician scientists and because of an historical focus at Mayo on translational science. The Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training, systematic exposure to clinical science, and a structured mentorship - with the goal of preparing each Fellow to become a future leader in Clinical Pharmacology.