Training Grant in Clinical Pharmacology

描述（由申请人提供）：本提案代表了对NIH申办的马约诊所-马约诊所医学院-马约医学院临床药理学研究金培训项目的持续资助请求。该计划的基础是应用于人药相互作用的最先进生物医学技术的强大研究培训。马约临床药理学培训经验包括一门课程，系统地使学员接触临床药理学基础科学的关键方面。培训的核心是在支持性的指导环境中获得出色的个人研究经验。临床药理学是研究药物与生物系统相互作用的桥梁学科。然而，在生物医学科学正在进行的“革命”的背景下，一场有望改变医疗实践的革命，临床药理学是分子药理学，基因组学，蛋白质组学，生物信息学和合理治疗的融合，最终目标是真正的“个性化”药物治疗。具体来说，临床药理学旨在提高我们对药物反应的分子基础的理解，并在翻译界面上应用这些信息，以便能够根据潜在的疾病过程和每个患者的独特特征定制药物治疗。我们有能力利用生物医学科学正在发生的巨大进步所代表的机会来实现这些目标，这将要求我们在“系统临床药理学”方面培养新一代临床药理学家。像马约诊所这样的大型、综合性、综合性学术医疗中心是培养新一代临床药理学家的理想场所。马约之所以能够做到这一点，是因为它有着悠久的整合历史。 由于对临床药理学学科的持续贡献的传统，以及马约临床药理学培训计划在成功招募和培训临床药理学领域的医生科学家和实验室转化科学家方面拥有数十年的经验，因此，梅奥是基础和临床医学研究的重要组成部分。在下一个资助周期中，马约临床药理学研究员培训计划将继续强调在支持性指导环境中进行强有力的基于实验室的研究培训，并系统地了解临床科学的发展，重点是生物医学科学的快速发展性质-所有这些都是为了使参加该计划的每位研究员成为临床药理学未来的领导者。

DESCRIPTION (provided by applicant): This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Clinic-Mayo Clinic College of Medicine-Mayo Medical School. The foundation for this program is strong research training in state-of-the-art biomedical techniques as applied to human-drug interactions. The Mayo Clinical Pharmacology training experience includes a curriculum that systematically exposes Trainees to critical aspects of the science that underlies Clinical Pharmacology. At the heart of the training is an outstanding individual research experience within a supportive mentoring environment. Clinical Pharmacology is a "bridge discipline" devoted to the study of the interaction between drugs and biological systems. However, within the context of the ongoing "revolution" that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of molecular pharmacology, genomics, proteomics, bioinformatics and rational therapeutics-with an ultimate goal of truly "individualized" drug therapy. Specifically, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and the application of that information at the translational interface to make it possible to tailor drug therapy to both he underlying disease process and the unique characteristics of each individual patient. Our ability to take advantage of the opportunity represented by the dramatic advances that are occurring in biomedical science to achieve those goals will require that we train a new generation of Clinical Pharmacologists in "Systems Clinical Pharmacology". Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of the integration of basic and clinical medical research, because of a tradition of continuous contribution to the discipline of Clinical Pharmacology and because the Mayo Clinical Pharmacology Training Program has had decades of experience in successfully recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training in a supportive mentored environment joined with systematic exposure to developments in clinical science, with an emphasis on the rapidly evolving nature of biomedical science-all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology.