How do p75 and sortilin facilitate TrkA-mediated survival signalling?

神经营养因子是一种经典的生长因子，在发育和成年动物的神经系统中调节神经元的存活和死亡。这些因子通过三种受体之一发出信号，但受体如何相互作用以促进细胞存活尚不清楚。这项资助的目的是解开支撑这种生死信号决定的分子基础，这样我们就可以设计出在神经退行性疾病中促进细胞存活的方法。

Neurotrophins are the classical growth factors that regulate neuronal survival and death throughout the nervous system in both the developing and adult animal. These factors signal through one of three receptors, but precisely how the receptors interact to propagate cell survival is unclear. The goal of this grant is to unravel the molecular basis underpinning this life and death signalling decision so that we can then devise ways to promote cell survival in neurodegenerative conditions