Development of Networked Implantable Neuroprostheses

描述（由申请人提供）：本项目是上肢网络神经假体（NNP）系统的可行性临床研究，以证明其对颈椎水平脊髓损伤患者提供抓握和伸手的有效性。NNP系统将电刺激瘫痪的肌肉以协调的方式提供抓握和释放、前臂旋前、肘部伸展和肩部/躯干稳定。通过植入的肌电记录电极，每位受试者将通过随意肌肉组织的激活来控制受刺激的模式。受试者的表现将通过损伤、活动和参与等指标进行评估，重点是更独立地进行日常生活活动的能力和日常家居使用率。我们假设，由于NNP系统的完全植入式特性，日常使用将得到改善，并且由于NNP系统的模块化和可定制特性，每个受试者的功能能力都将得到改善，而不管他们的初始功能水平如何。

DESCRIPTION (provided by applicant): This project is a feasibility clinical study of the upper extremity Networked Neuroprosthetic (NNP) System to demonstrate efficacy in providing grasp and reach for individuals with cervical level spinal cord injury. The NNP System will electrically stimulate paralyzed muscles in a coordinated fashion to provide grasp and release, forearm pronation, elbow extension, and shoulder/trunk stabilization. The stimulated patterns will be controlled by each subject through activation of their voluntary musculature, as recorded through implanted myoelectric recording electrodes. Subject performance will be assessed through measures of impairment, activities, and participation, with a focus on the ability to perform activities of daily living more independently and on the rate of daily home use. We hypothesize that daily usage will be improved due to the fully implantable nature of the NNP System and that every subject will improve in their functional ability, regardless of their startin function level, due to the modular and customizable nature of the NNP System. PUBLIC HEALTH RELEVANCE: This project is designed to develop and evaluate an advanced, fully-implantable hand neuroprosthesis for individuals with spinal cord injury. The study is relevant to individuals with cervical level spinal cord injury because it provides them with the ability to use their hand and arm more independently.