Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei

大规模T细胞表位发现计划的目标是建立和支持几个高度互动的多学科团队，专注于大规模发现与新出现和重新出现的传染病相关的微生物以及生物恐怖主义及其毒素的潜在病原体。新的T细胞表位的发现和验证将有助于疫苗的设计和开发；改进的基于免疫的疗法；以及预防、治疗和检测此类感染的诊断工具，通过提供关键信息来选择诱导T细胞激活的MHC-肽或其他MHC-配体复合体，以产生和维持保护性免疫。

The goal of the Large Scale T Cell Epitope Discovery program is to establish and support several highly interactive, multi-disciplinary teams focused on large scale discovery of T cell epitopes associated with microorganisms responsible for emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. The discovery and validation of novel T cell epitopes will facilitate the design and development of vaccines; improved immune-based therapeutics; and diagnostic tools for the prevention, treatment and detection of such infections, by providing critical information needed to select MHC-peptide or other MHC-ligand complexes that induce T cell activation for the generation and maintenance of protective immunity.