Compact swept Near-Infrared Light Source for Broadband Diffuse Optical Spectrosco

描述（由申请人提供）：本项目将开发一种扫描近红外光源，使便携式高光谱层析功能光学成像仪成为可能。虽然这样的设备在内源性近红外光谱和成像或分子成像光谱中有许多应用，但我们将重点关注光源在为乳房成像设计的仪器中的应用。长期目标是开发一种结合5-10个单独芯片的源，形成一个非常紧凑（0.5 cm x0.5cm x0.5cm）的扫描源，扫描范围为200-400nm，扫描速度为10-100msec，输出功率为10mW。该光源将被整合到手持式功能性漫射光谱成像设备中（不需要外源性造影剂），以监测和预测乳腺癌治疗中的化疗反应。加州大学欧文分校开发的DOSI仪器目前正在美国国立卫生研究院支持的一项多中心临床试验中对新辅助患者进行验证。扫描近红外光源将提高手持式DOSI仪器的性能和商业化潜力，因为它允许3D地下成像，通过向探测器提供更高的光子强度来提高图像的信噪比，并允许设备的小型化，以便与常规临床使用兼容。第一阶段项目将展示基于集成VCSEL-MEMs技术的扫描光源。该器件的输出光波长将以850nm为中心，输出功率为1mW，调谐范围为35nm，调谐速率为10msec。在第一阶段的项目中，这个初始的原型设备将被插入到DOSI手持式探头中，并将

DESCRIPTION (provided by applicant): This project will develop a swept near-infrared light source that enables a portable hyperspectral tomographic functional optical imager. While such a device has many applications within endogenous NIR spectroscopy and imaging, or molecular imaging spectroscopy, we will focus on the application of the light source within an instrument designed for breast imaging. The long term goal is to develop a source that combines 5-10 individual chips to form a very compact (0.5 cm x 0.5cm x0.5cm) swept source with a range of 200-400nm, a scanning speed of 10-100msec and an output power of 10mW. This source would be incorporated into a handheld functional Diffuse Optical Spectroscopic Imaging device (not requiring exogenous contrast agents) to monitor and predict chemotherapy response in the treatment of breast cancer. A DOSI instrument developed at UC Irvine is currently undergoing validation on neoadjuvant patients in a multi-center clinical trial supported by the NIH. The swept NIR source would improve the performance and commercialization potential of a handheld DOSI instrument by allowing 3D subsurface imaging, improving the signal to noise ratio of the image by delivering a much higher photon intensity to the detector, and allowing the miniaturization of the device so that it is compatible with routine clinical use. The Phase I projet will demonstrate a swept optical source based upon an integrated VCSEL-MEMs technology. The output optical wavelength of the device will be centered at 850nm, and will demonstrate an output power of 1mW, and a tuning range of 35nm with a tuning rate of 10msec. During the Phase I project, this initial prototype device will be inserted into a DOSI handheld probe and will be used to measure the optical properties in a breast tissue simulating phantom. The phase II project will optimize the device performance, and extend it to the full range of wavelengths (multiple VCSEL- MEMs die that together span the entire desired wavelength range) and will be implemented in a handheld imager to demonstrate full imaging functionality. PUBLIC HEALTH RELEVANCE: This project will develop an optical light source that enables improved tomographic functional optical imaging for detecting, characterizing and therapeutic monitoring of breast cancer. Key applications include screening for breast cancer for younger women, as well as monitoring the effectiveness of neoadjuvant chemotherapy. The optical source is expected to enable improved image signal to noise, contrast, and imaging depth.