A Data Coordinating Center for ENCODE

描述（由申请人提供）：ENCODE数据库协调和分析中心的ENCODE数据协调（DCC）组件的目标是通过定义和建立将所有参与者连接到数据的管道，以及通过创建将这些数据分发给更大的生物研究社区的访问途径来支持ENCODE联盟。ENCODE联盟将通过实验分析生成复杂数据类型的实验室与使用计算分析整合这些独特数据的实验室结合在一起，以发现染色体元件如何共同作用来定义人类细胞。数据中心的参与增强了这些实验室创建的数据，具体做法是建立结构化管道，对所有提交的数据进行核查和验证，并提供记录描述每种生物样本和分析方法的元数据的流程。为了方便访问以前的ENCODE项目创建的所有数据以及modENCODE项目的数据和任何其他确定适合合并的大型数据集，DCC将构建一个称为大数据中心的最先进的数据存储库。数据协调委员会将设计和开发新的软件，以加强数据提交和处理管道、元数据的组织和访问以及大数据中心。此外，我们将创建ENCODE门户，这将是丰富的实验确定的信息以及计算分析结果的主要入口点。门户网站将整合这些数据资源，并通过增强的搜索和浏览能力提供这些资源。将实施工具，以帮助发现经验丰富的生物信息学家和天真的实验室工作人员。DCC将发展成为一个实质性的服务组织，使生物医学研究能够充分利用ENCODE的成果。为此，DCC将通过许多媒体提供文档，包括书面文档，视频教程，网络研讨会和会议演示。DCC、DAC和AWG将紧密编织在一起，以创建EDCAC。 公共卫生相关性：这项工作与公共卫生的相关性在于，全面确定人类基因组编码的功能元件对于了解人类健康的性质和疾病的治疗至关重要。 项目/

DESCRIPTION (provided by applicant): The goals of the ENCODE Data Coordinating (DCC) component to the ENCODE Database Coordination and Analysis Center are to support the ENCODE Consortium by defining and establishing pipelines that connect all participants to the data and by creating avenues of access that distribute these data to the greater biological research community. The ENCODE Consortium brings together laboratories that generate complex data types via experimental assays with laboratories that integrate these unique data using computational analyses to discover how chromosomal elements function together to define the human cell. The DCC's participation enhances the data created by these laboratories through the creation of structured pipelines for the verification and validation of all submitted data and providing processes for the documentation of metadata that describe each biological sample and assay method. To facilitate access to all the data created by the previous ENCODE projects as well as data from the modENCODE project and any other large data collections that are determined to be appropriate for incorporation, the DCC will construct a state of the art data storage repository called the Big Data Hub. The DCC will design and development new software to enhance the data submission and processing pipeline, the organization and access to metadata and the Big Data Hub. In addition, we will create the ENCODE Portal that will be the primary entry point to the wealth of experimentally determined information as well as results of computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Tools will be implemented to aid discovery by both experienced bioinformaticians and naive laboratory staff. The DCC will evolve into a substantial service organization allowing biomedical research to take full advance of the ENCODE results. To this end the DCC will provide documentation via many media including written documentation, video tutorials, webinars, and meeting presentations. The DCC, DAC, and AWG will be tightly woven together to create the EDCAC. PUBLIC HEALTH RELEVANCE: The relevance of this work for public health is that the comprehensive determination of functional elements encoded by the human genome is essential for understanding the nature of human health and the treatment of disease. PROJECT/