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Role of Gq/11-alpha in metabolic regulation

Role of Gq/11-alpha in metabolic regulation
Gq/11-alpha 在代谢调节中的作用
批准号：
8349964
负责人：
Lee Weinstein
金额：
$19.89万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349964
关键词：
AllelesEatingEnergy MetabolismEnvironmentEnzymesGTP-Binding ProteinsGenesGoalsHormonesHouse miceHypothalamic structureLifeMetabolicMorbid ObesityMusNeuraxisNeurotransmittersPeripheralPhenotypePhospholipase CPlayRegulationRoleSignal TransductionTissuesTransgenesTransgenic MiceUnderweightWeight Gainextracellularglucose metabolismparaventricular nucleuspromoterreceptor couplingrecombinase

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中文摘要
翻译
迄今为止，我们已经使用Sim1-cre转基因小鼠在下丘脑室旁核（PVN）产生Gq/11- α缺陷小鼠。初步研究结果显示，这些老鼠在出生后的第一个月体重不足，但随后会发展成严重的肥胖。然而，当老鼠单独饲养时，它们不会增加体重，这表明环境可能会影响表型。目前正在进行研究，以确定这在多大程度上是由于食物摄入过多与能量消耗减少造成的。
英文摘要
To date we have generated mice with Gq/11-alpha deficiency in the paraventricular nucleus of the hypothalamus (PVN) using Sim1-cre transgenic mice. Preliminary findings show that these mice are underweight in the first month of life but then do develop severe obesity. However when the mice are housed individually they do not gain weight, suggesting that environment may imppact on the phenotype. Studies are underway to determine to what extent this is due to excess food intake vs. reduced energy expenditure.
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