Neuroimaging Core (Page 433)

神经成像核心的总体目标是为HNRC和协作调查人员提供 用于：1)使用广泛的技术对HLV相关脑损伤进行活体检测，包括 结构、功能、代谢、磁化率和扩散加权磁共振成像和正电子发射 体层摄影术(PET)；2)死后磁共振成像，以阐明导致 这种损害；3)这些成像的认知后果和神经医学相关性的调查 效果；以及4)确定治疗成功的潜在生物标志物。在本资助期内， CORE支持了30多个项目，结果是，例如，发现了可检测到的脑脊液艾滋病毒 随着时间的推移，白质损伤增加，基线上的病毒载量增加；结构、扩散和 脑白质损伤的组织病理学证据；脑白质束弥散系数降低与 认知障碍；以及与艾滋病毒相关的豆状体区脑血流减少。培训和 为31名个人提供了咨询，从而为艾滋病毒和艾滋病研究招募了新的调查人员 在国家和国际环境中扩大神经成像技术的使用。其他内容 合作推进了我们的目标，即扩大有效的神经成像方法的范围，以便 在艾滋病毒研究中的使用。我们在拟议的续期中的目标是：a)提供资源、咨询和 为神经成像提供技术援助；b)获取和分析活体和死后图像，以支持 临床解剖学工作和试点研究；c)为改进的 用于艾滋病毒的图像获取和分析方法；以及d)教育研究界 有望为神经艾滋病研究提供新的成像方法。扩展的核心包括血管和PET 淀粉样蛋白成像，以推进对老龄化艾滋病毒人口的研究。此外，通过地方、国家和 国际合作，核心将强调方法验证和跨成像的数据集成 艾滋病毒的使用方式，可能导致更好地了解艾滋病毒对中枢神经系统的影响的方法 感染。该核心将通过与HNRC的 神经行为学、神经医学、神经病毒学和神经生物学核心。这些范围广泛的函数 确保为HNRC相关研究提供最先进的支持，与跨学科紧密结合 HNRC调查团队，并参与国家和国际神经成像社区。

The overall goal of the Neuroimaging Core is to provide the HNRC and collaborative investigators with resources for: 1) in vivo detection of HlV-related brain injury using a broad array of techniques, including structural, functional, metabolic, susceptibility and diffusion weighted MRI, and positron emission tomography (PET); 2) post-mortem MR imaging for elucidation of pathological mechanisms that give rise to this damage; 3) investigations of the cognitive consequences and neuromedical correlates of these imaging effects; and 4) identification of potential biomarkers for treatment success. In the current funding period, the Core has supported more than 30 projects, resulting in, for example, findings linking detectable CSF HIV viral load at baseline with increases in white matter damage over time; integration of structural, diffusion and histopathological evidence of white matter damage; correlation of reduced white matter tract diffusivity with cognitive impairment; and HIV-associated reductions in cerebral blood flow in lenticular regions. Training and consultation were provided for 31 individuals, resulting in recruiting new investigators to the study of HIV and expanding the use of neuroimaging techniques in national and international settings. Additional collaborations have advanced our goals to expand the range of valid neuroimaging methods available for use in HIV research. Our aims in the proposed renewal period are to: a) provide resources, consultation, and technical assistance for neuroimaging; b) acquire and analyze in vivo and postmortem images to support clinico-anatomic work and pilot studies; c) contribute data and expertise for the development of improved image acquisition and analytic methods for use in HIV; and d) educate research communities regarding promising new imaging approaches for neuroAIDS research. The expanded Core includes vascular and PET amyloid imaging, to advance the study of an aging HIV population. Furthermore, through local, national, and international collaborations, the Core will emphasize method validation and data integration across imaging modalities for use in HIV, approaches that may lead to a better understanding of the CNS effects of HIV infection. This Core will enhance HNRC transdisciplinary aims through close collaboration with the Neurobehavioral, Neuromedical, Neurovirology, and Neurobiology Cores. These broad-ranging functions ensure state of the art support for HNRC-associated studies, close integration with the interdisciplinary HNRC investigative team, and participation in national and international neuroimaging communities.