Studies of other risk factors for radiosensitive tumors

我们正在进行两项试验性研究，以检验（1）对两个县的500个家庭进行随访和参与访谈的可行性，其中两个县在20世纪90年代中期开展了社区干预计划（CIP），（2）确定1994年出生的儿童中发生的儿童癌症。96在医院服务的CIP人口和能力，这些儿科癌症患者联系回CIP人口。1994 ~ 1996年在北京东北和南部的三个大县进行的CIP社区干预计划试验，评价了围受孕期补充叶酸对减少神经管缺陷的有效性。在围受孕期服用叶酸补充剂的母亲的后代神经管缺陷显著减少。西方国家过去10年的病例对照流行病学研究表明，围受孕期补充叶酸可能会降低服用这些补充剂的母亲的后代患儿童白血病和其他儿童癌症的风险。其他的研究也显示了围产期叶酸和包括哮喘在内的后代严重慢性疾病之间的统计学关联。试点研究将尝试追踪、招募和访问来自江苏太仓和河北乐亭的500个家庭，并将寻求确定1994年至1996年出生的儿童中1994年至今诊断的所有儿科癌症，并将这些儿童与CIP队列联系起来。

Childhood Cancer In Chinese Children and Family Cohorts We are conducting two pilot studies to test the feasibility of (1) follow and participation in interviews of a sample of 500 families from two county sites where the Community Intervention Program (CIP) was carried out in the mid-1990s and (2) identification of incident pediatric cancers arising among thoseborn during 1994-96 in hospitals serving the CIP population and ability to link these pediatric cancer patients back to the CIP population. The CIP community intervention program trial, which was carried out during 1994-96 in three large counties northeast and south of Beijing, evaluated the effectiveness of periconceptional folic acid supplements in reducing neural tube defects. There were dramatic reductions in neural tube defects among offspring of mothers who took folic acid supplements during the periconceptional period. Publications from case-control epidemiologic studies in the past 10 years from Western countries have shown that periconceptional folic acid supplements may reduce risks of pediatric leukemia and potentially other pediatric cancers in offspring of mothers who take these supplements. Other studies have shown statistical associations with periconception folic acid and other serious chronic diseases of offspring including asthma. The pilot studies will attempt to trace, enroll, and interview 500 families from Taicang, Jiangsu Province and Laoting, Hebei Province and will seek to identify all pediatric cancers diagnosed during 1994 to the present among children born during 1994-96 and link these children back to the CIP cohort.