Study the chromatin binding proteins in embryonic stem cells
Study the chromatin binding proteins in embryonic stem cells
批准号:
8349431
负责人:
Jing Huang
金额:
$40.48万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Binding ProteinsBone Marrow TransplantationCell TherapyCellsChromatinClinicalDNA SequenceDatabasesEpigenetic ProcessEventGene ExpressionMiningMolecularOutcomePlayProcessProteinsRoleSourceStem cellsadult stem cellcell typeclinical applicationembryonic stem cellgenome-wideinsightnerve stem cellstem cell differentiationstem cell therapy
中文摘要
干细胞治疗在临床上具有巨大的应用潜力。ES细胞是产生所有不同类型成体干细胞的无限来源。然而,ES细胞分化为成体干细胞的过程尚不清楚,尽管认为表观遗传事件对这一过程至关重要。我们计划研究ES细胞中的染色质结合蛋白。染色质结合蛋白是调节表观遗传事件的关键蛋白质。因此,本研究将有助于从分子水平上了解胚胎干细胞的分化过程,为胚胎干细胞的临床应用提供基础。
英文摘要
Stem cell therapy have great potentials in clinical application. ES cells represent an unlimited source to generate all different types of adult stem cells. However, the events during the differentiation of ES cells into adult stem cells are unclear, although it is thought that epigenetic events are critical for this process. We plan to study the chromatin binding proteins in ES cells. Chromatin binding proteins are proteins which are critical for regulating the epigenetic events. Therefore, this project will provide molecular insights into the differentiation process of ES cells and faciliate the clinical utilization of ES cells.
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会议论文
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