核心 B：行为核心-猫眼课题宝

核心 B：行为核心

批准号：

8311881

负责人：

Shelly Beth Flagel

金额：

$20.46万

依托单位：

UNIVERSITY OF MICHIGAN AT ANN ARBOR

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8311881

关键词：

Animal Behavior Animals Behavior Behavioral Body Weight Catheters Core Facility Cues Data Development Diet Female Food Food deprivation (experimental)Foundations Goals Hour Housing Human Resources Humidity Incentives Individual Individual Differences Instruction Intervention Laboratories Learning Light Lighting Location Measures Methods Monitor Neurobiology Operative Surgical Procedures Pain Pharmaceutical Preparations Pilot Projects Pre-Clinical Model Procedures Property Protocols documentation Public Health Quality Control Rattus Reaction Time Reporting Research Research Personnel Rewards Risk Factors Schedule Self Administration Series Sex Characteristics Shapes Source Sprague-Dawley Rats Standardization Supervision Surgical Flaps Tail Temperature Terminology Testing Thinking Training United States Variant Water Weight Weight Gain addiction approach behavior base behavior test classical conditioning deprivation design indexing male motivational processes premature prevent programs psychologic research study response sex trait

项目摘要

项目成果

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中文摘要

翻译

项目总结（见说明）：行为核心将服务于本申请中提出的所有个别项目。除了对项目中使用的所有动物的饲养进行监督外，还有许多行为测试程序对所有项目都是通用的，这些程序将在行为核心中进行。这包括最初的行为测试，以量化被认为有助于成瘾的“特质”，包括将激励显着性归因于奖励线索的倾向（通过奖励线索的巴甫洛夫方法测量）和做出“冲动行为”的倾向（通过对2选择序列反应时间任务的过早反应测量）。此外，在可行和适当的情况下，将在行为核心中进行药物自我给药试验。行为核心的实施将确保一定程度的“质量控制”和标准化，这将大大减少差异，并促进各个项目结果的比较。

英文摘要

PROJECT SUMMARY (See instructions): The Behavioral Core will serve all individual Projects proposed in this application. In addition to the supervision of husbandry for all animals to be used in the Projects, there are a number of behavioral test procedures that are common to all Projects and these will be conducted in the Behavioral Core. This includes initial behavioral testing to quantify "traits" that are thought to contribute to vulnerability to addiction, including the propensity to attribute incentive salience to reward cues (measured by Pavlovian approach to reward cues) and the propensity to make "impulsive actions" (measured by premature responses on a 2-choice serial reaction time task). In addition, drug self-administration testing will be conducted in the Behavioral Core, when feasible and appropriate. The implementation of the Behavioral Core will insure a level of "quality control" and standardization that will significantly reduce variance and facilitate the comparison of results across individual Projects.

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