EFFECT OF VISCERAL FAT ON INSULIN SENSITIVITY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 过多的腹内（内脏）脂肪与代谢性疾病的风险增加有关，包括2型糖尿病，糖尿病和高血压。然而，目前尚不清楚内脏脂肪是否真的是这些代谢异常的原因，或者只是与这些代谢异常有关。该提案将评估通过切除超重雄性狒狒的网膜来减少腹内脂肪量的代谢效应，并将确定所涉及的机制。预计该手术将改善肌肉/脂肪组织和肝脏对胰岛素（2型糖尿病的风险因素）的敏感性，降低肝脏和肌肉中的炎症水平。因此，获得的信息将有助于临床医生和研究人员集中精力减少肥胖相关代谢疾病的社会负担。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.