DEVELOPMENT OF A RHESUS MONKEY MODEL FOR IN UTERO CHIKUNGUNYA VIRUS INFECTION

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 基孔肯雅病毒（CHIKV）是一种与人类衰弱性关节痛流行病相关的蚊媒甲病毒。从2005年到2007年，来自东非的CHIKV基因型传播到印度，导致爆发了200万人病例。除了疫情规模外，还发现了新的神经系统综合征，包括与新生儿传播相关的胎儿脑病。目前尚不确定这些新型综合征是毒力增强、组织嗜性改变的结果，还是仅仅反映了疫情规模和病例报告的改善。尽管最近已经开发了CHIKV小鼠模型，但非人灵长类动物具有更能反映人的生理特征，因此允许更准确地表示人CHIKV嗜性和临床综合征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of debilitating arthralgia in humans. From 2005-2007, a CHIKV genotype from East Africa crossed to India, leading to an outbreak with 2 million human cases reported. In addition to the outbreak magnitude, novel neurological syndromes were identified, including fetal encephalopathy associated with neonatal transmission. It remains to be determined whether the novel syndromes are the result of increased virulence, altered tissue tropism or are merely reflective of the outbreak size and improved case reporting. Although a CHIKV mouse model has recently been developed, non-human primates possess physiological characteristics more reflective of humans, thus allowing for a more accurate representation of human CHIKV tropism and clinical syndromes.