IMMUNE MODULATION OF THE FETUS BY INTRA-AMNIOTIC IL-1

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 支气管肺发育不良(BPD)是极低出生体重(VLBW)新生儿最常见的并发症，在美国约有15,000名婴儿确诊。BPD会导致终生肺部残疾，并与神经发育缺陷有关。IL-1/IL-17轴已被证明是参与这些极低出生体重儿肺部炎症发展的关键机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bronchopulmonary dysplasia (BPD) is the most common complication in very low birth weight (VLBW) newborns, and is diagnosed in about 15,000 infants in the U.S. BPD results in lifelong pulmonary disabilities and is associated with neurodevelopmental deficits. The IL-1/IL-17 axis has been shown to be a critical mechanism involved in the development of lung inflammation in these VLWB preterm babies.