COBRE: OUHSC: ANIMAL CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 科布雷的动物舱为OUHSC校园内的所有视觉研究人员提供高质量的动物护理和视觉相关实验的技术援助。小鼠、大鼠和兔子的栖息地包括常规环境、微隔离环境和生物危害环境。动物舱中提供的设备包括视网膜电描记术、光学相干断层扫描、验光、显微外科手术、显微注射、玻璃体切除、血管造影术、眼底镜、暗适应、光曝光以及数字摄影和录像系统。转基因育种群体已被开发和建立，促进了与视网膜变性、青光眼、胰岛素受体、糖尿病、细胞因子合成和先天性免疫识别系统有关的特定基因和因素的分析。OUHSC的所有视觉和非视觉研究人员都可以使用这种多样化的转基因菌株，并促进了不同专业领域的研究人员之间富有成效的合作。动物模块是使用最频繁的Cobre模块，对于Cobre PJI和ECI的研究计划来说是绝对必要的。OUHSC视力研究的增长和随后动物需求的增加需要扩展到OUHSC校园中更多的动物空间。随着设施扩建在未来两年内完成，DMEI的可用动物空间预计将翻一番。这些重大改进将促进Cobre PJI和ECIS研究计划的发展，并促进OUHSC视觉研究的增长。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Animal Module of the COBRE serves all vision researchers on the OUHSC campus with high-quality animal care and technical assistance with vision-related experiments. Housing for mice, rats, and rabbits includes conventional, microisolation, and biohazard environments. Equipment available in the Animal Module includes systems for electroretinography, optical coherence tomography, optomotry, microsurgery, microinjection, vitrectomy, angiography, funduscopy, dark adaptation, light exposure, and digital photography and videography. Transgenic breeding colonies have been developed and established, facilitating the analysis of specific genes and factors involved in retinal degeneration, glaucoma, insulin receptor, diabetes, cytokine synthesis, and innate immune recognition systems. This varied collection of transgenic strains is available to all vision and non-vision researchers at OUHSC and has facilitated fruitful collaborations among researchers in differing areas of expertise. The Animal Module is the most heavily used COBRE module and is absolutely essential to the research programs of the COBRE PJIs and ECIs. Growth of vision research at OUHSC and subsequent increases in animal needs necessitates expansion into additional animal space on the OUHSC campus. An estimated doubling of available animal space is projected at DMEI with the completion of facility expansion in the next 2 years. These major improvements will facilitate the development of the COBRE PJIs' and ECIs' research programs and the growth of vision research at OUHSC.