REGULATORY ROLE OF HEPARAN SULFATE ON SLIT3/ROBO-MEDIATED ANGIOGENESIS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Sit/Robo信号通路是调控血管生成的一条新途径。我们最近的研究发现，硫酸肝素对SLIT3/Robo途径介导的血管生成具有重要的调节作用。在这项合作研究中，我们旨在阐明Sit/Robo信号在血管生成中的机制，并阐明在血管生成中调节SLIT3/Robo信号所需的硫酸乙酰肝素的精细结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Slit/Robo signaling has been established as a novel pathway that modulates angiogenesis. Our recent studies found that heparan sulfate critically modulates Slit3/Robo pathway-mediated angiogenesis. In this collaborative study we aim to elucidate the mechanism of Slit/Robo signaling in angiogenesis, and to elucidate the fine structure on heparan sulfate that is required to modulate Slit3/Robo signaling in angiogenesis.