ATLASTIN

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Alastin是新近发现的一种依赖GTP的细胞膜FusoGen。它是一个~60 kDa的积分 在其C末端附近有两个跨膜区的膜蛋白。Atlastin驱动器 体内和体外同型内质网融合。我们最近重组了 阿特拉斯汀介导的重组蛋白和蛋白脂质体的融合[Orso等，自然， 2009,460(7258)：978-83]。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alastin is a newly identified GTP-dependent membrane fusogen. It is an ~60 kDa integral membrane protein with two transmembrane domains near its C-terminus. Atlastin drives homotypic endoplasmic reticulum fusion in vitro and in vivo. We have recently reconstituted atlastin-mediated fusion with recombinant protein and proteoliposomes [Orso et al, Nature, 2009, 460(7258):978-83].