FREQUENCY DOMAIN PHOTON MIGRATION OF HEMORRHAGIC SHOCK

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 随着技术、医学和对急性疾病的理解的进步，出现了对开发快速、准确和无创地监测患者失血、血流、氧气输送的变化和对复苏的响应的需求。 此外，在大规模危及生命的伤害的情况下，例如在战争、重大创伤或自然灾害的情况下，识别伤害的严重程度和适当的分类对于资源利用和提供适当的救生护理至关重要。 本计画的目的是探讨一种无创红外线监测装置在失血性休克诊断与治疗上的应用与发展。 该装置将为医生和护理人员提供等同于或上级于当前标准实践的非侵入性生理监测能力，并且能够以快速速率采样。 该装置正在失血性休克的动物模型中进行测试。 从这些实验中收集的数据将与标准侵入性监测相关联，以确定准确性和可靠性。 将监测使用IV液体和2种血液替代品对诱导性休克进行的治疗或复苏。 从复苏工作中获得的数据将证明该器械能够监测治疗过程中的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. As technology, medicine, and the understanding of acute illness has progressed, a need has arisen for the development of rapid, accurate, and non-invasive monitoring of patient blood loss, blood flow, changes in oxygen delivery, and response to resuscitation. Moreover, in the setting of massive life threatening injuries, such as in war, major trauma or in cases of natural disaster, recognition of severity of injury and appropriate triage are critical to resource utilization of and delivery of appropriate life saving care. The purpose of this proposal is to investigate the use and development of a non-invasive infrared monitoring device for the diagnosis and treatment of hemorrhagic shock. This device would provide physicians and care takers with non-invasive physiologic monitoring capabilities equal or superior to that of current standard practice and capable of sampling at a rapid rate. The device is being tested in an animal model of hemorrhagic shock. Data collected from these experiments will be correlated with standard invasive monitoring to determine accuracy and reliability. Treatment or resuscitation of induced shock using IV fluids and 2 blood substitutes will be monitored. Data obtained from resuscitation efforts will demonstrate the devices ability to monitor response to treatment in process.