SYNTHESIS OF NEW ORGANIC MOLECULES TO ADDRESS IMPORTANT METAL-MEDIATED PROCESSES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们的研究计划使用无机化学、有机化学和生物化学来解决与能源、生物和医学相关的重要金属中介过程。将采用跨学科、基于问题的方法来合成和表征新的有机分子和无机络合物，最终目标是解决对我们的社会具有广泛影响的悬而未决的问题。这三个主要的研究领域预计将吸引具有不同研究兴趣的学生和博士后，并为他们提供适用于大多数化学职业的广泛知识基础。 非血红素铁酶。非血红素铁酶催化广泛的氧化和氧化反应。本项目旨在利用O2激活的非血红素铁酶的底物专一性来设计和合成该酶的特异性抑制剂。 可再生能源催化。由于人口和经济的增长，预计未来50年全球能源消费将至少翻一番。在这种背景下，人们对开发能够捕捉太阳能并利用其从水中生产氧气和氢气的分子系统产生了极大的兴趣。该项目致力于多金属络合物的设计、合成和表征，作为潜在的水氧化催化剂。 阿尔茨海默病中的淀粉样多肽。阿尔茨海默病(AD)是最常见的神经退行性疾病。阿尔茨海默病患者的大脑以淀粉样蛋白b(Ab)肽斑块的沉积为特征，这些斑块积累了异常高浓度的铜、铁和锌。本项目旨在研究过渡金属离子与抗体多肽的相互作用，以及金属离子在淀粉样蛋白斑块和活性氧物种(ROS)形成中的作用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our research program uses inorganic chemistry, organic chemistry, and biological chemistry to address important metal-mediated processes with energy, biological, and medical relevance. An interdisciplinary, problem-based approach will be employed to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to tackle unsolved problems with broad implications to our society. Three main research areas will be pursued, which are expected to attract students and postdocs with different research interests and to provide them with a broad knowledge base applicable in most chemistry careers. Non-Heme Iron Enzymes. Non-heme iron enzymes catalyze a wide range of oxidation and oxygenation reactions. This project aims to design and synthesize specific inhibitors of O2-activating non-heme iron enzymes by taking advantage of the enzyme's substrate specificity. Renewable Energy Catalysis. The global energy consumption is expected to at least double in the next fifty years due to population and economic growth. In this context, there is a large interest in developing molecular systems that can capture solar energy and used it to produce oxygen and hydrogen from water. This project regards the design, synthesis, and characterization of polymetallic complexes as potential catalysts for water oxidation. Amyloid b Peptides in Alzheimer's Disease. Alzheimer's Disease (AD) is the most common neurodegenerative disease. The brains of patients with AD are characterized by the deposition of amyloid b (Ab) peptide plaques, which accumulate unusually high concentrations of copper, iron, and zinc. This project is directed toward the investigation of the interaction of transition metal ions with Ab peptides and the study of the role of metal ions in amyloid plaque and reactive oxygen species (ROS) formation