SYNTHESIS OF NEW ORGANIC MOLECULES TO ADDRESS IMPORTANT METAL-MEDIATED PROCESSES

合成新的有机分子以解决重要的金属介导的过程

• 批准号: 8168834
• 负责人: LIVIU M. MIRICA
• 金额: $ 1.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168834
• 关键词: Address; Alzheimer' s Disease; Amyloid; Amyloid deposition; Area; Biochemistry; Biological; Brain; Catalysis; Chemistry; Complex; Computer Retrieval of Information on Scientific Projects Database; Consumption; Copper; Economics; Enzymes; Funding; Goals; Grant; Growth; Heme Iron; Hydrogen; Inorganic Chemistry; Institution; Investigation; Ions; Iron; Mediating; Medical; Metals; Molecular; Neurodegenerative Disorders; Organic Chemistry; Oxygen; Patients; Peptides; Population; Process; Reaction; Reactive Oxygen Species; Research; Research Personnel; Resources; Role; Senile Plaques; Societies; Solar Energy; Source; Students; Substrate Specificity; System; Transition Elements; United States National Institutes of Health; Water; Zinc; base; career; catalyst; design; enzyme substrate; inhibitor/antagonist; interest; knowledge base; oxidation; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program uses inorganic chemistry, organic chemistry, and biological chemistry to address important metal-mediated processes with energy, biological, and medical relevance. An interdisciplinary, problem-based approach will be employed to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to tackle unsolved problems with broad implications to our society. Three main research areas will be pursued, which are expected to attract students and postdocs with different research interests and to provide them with a broad knowledge base applicable in most chemistry careers. Non-Heme Iron Enzymes. Non-heme iron enzymes catalyze a wide range of oxidation and oxygenation reactions. This project aims to design and synthesize specific inhibitors of O2-activating non-heme iron enzymes by taking advantage of the enzyme's substrate specificity. Renewable Energy Catalysis. The global energy consumption is expected to at least double in the next fifty years due to population and economic growth. In this context, there is a large interest in developing molecular systems that can capture solar energy and used it to produce oxygen and hydrogen from water. This project regards the design, synthesis, and characterization of polymetallic complexes as potential catalysts for water oxidation. Amyloid b Peptides in Alzheimer's Disease. Alzheimer's Disease (AD) is the most common neurodegenerative disease. The brains of patients with AD are characterized by the deposition of amyloid b (Ab) peptide plaques, which accumulate unusually high concentrations of copper, iron, and zinc. This project is directed toward the investigation of the interaction of transition metal ions with Ab peptides and the study of the role of metal ions in amyloid plaque and reactive oxygen species (ROS) formation

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究计划使用无机化学，有机化学和生物化学来解决与能源，生物和医学相关的重要金属介导的过程。一个跨学科的，基于问题的方法将被用来合成和表征新的有机分子和无机复合物，最终目标是解决未解决的问题，对我们的社会产生广泛的影响。三个主要的研究领域将继续进行，预计将吸引学生和博士后与不同的研究兴趣，并为他们提供广泛的知识基础，适用于大多数化学职业。 非血红素铁酶。非血红素铁酶催化广泛的氧化和加氧反应。本项目旨在利用非血红素铁酶的底物特异性，设计合成非血红素铁酶的特异性抑制剂。 可再生能源催化剂。由于人口和经济增长，全球能源消耗预计在未来50年内至少翻一番。在这种情况下，人们对开发能够捕获太阳能并利用其从水中产生氧气和氢气的分子系统有很大的兴趣。本项目将设计、合成和表征多金属配合物作为水氧化的潜在催化剂。 阿尔茨海默病中的淀粉样B肽阿尔茨海默病（Alzheimer's Disease，AD）是最常见的神经退行性疾病。AD患者的脑的特征在于淀粉样蛋白B（Ab）肽斑块的沉积，其积累异常高浓度的铜、铁和锌。本项目旨在研究过渡金属离子与抗体肽的相互作用，以及金属离子在淀粉样斑块和活性氧形成中的作用