BORONATED TUMOR SEEKING PORPHYRINS SYNTHESIS & TESTING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目致力于设计和合成用于癌症的硼中子俘获治疗的硼化卟啉和其他分子。这些化合物随后将在小动物身上进行测试。由于这主要是一个合成有机项目，质谱学是该项目中用于表征化合物的一个极其重要的方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project focuses on the design and synthesis of boronated porphyrins and other molecules for boron neutron capture therapy of cancer. These compounds will subsequently be tested in small animals. Since this is predominantly a synthetic organic project, mass spectrometry is an extremely important aspect of the project for use in characterizing the compounds.