STRUCTURAL STUDIES OF HUMAN SERYL-TRNA SYNTHETASE IN ANGIOGENESIS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 人类丝氨酰-tRNA合成酶(SerRS)是一种II类氨基酰tRNA合成酶，也是翻译途径中的一个重要酶，被发现与血管发育和血管生成有关。身体？S失去对血管生成的控制，导致70多种主要健康疾病，影响全球超过10亿人。新血管形成不足(血管生成)与冠状动脉疾病、中风和慢性伤口有关。另一方面，过度的血管生成也是有害的，并与癌症、糖尿病失明、老年性黄斑变性、类风湿性关节炎和牛皮癣等疾病有关。最近发现，SerRs通过VEGFA/VEGFR2信号通路在血管生成中发挥重要作用。人类SerRs的晶体结构以及SerRs与其潜在相互作用伙伴的复合体的晶体结构将为理解tRNA合成酶在血管生成调控中的作用提供重要的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Human seryl-tRNA synthetase(SerRS), a class II aminoacyl?tRNA synthetase and an essential enzyme of the translational pathway, was found to be associated with in vascular development and angiogenesis. The body?s loss of control over angiogenesis causes more than 70 major health conditions affecting over one billion people worldwide. Insufficient formation of new blood vessels (angiogenesis) is connected to coronary artery disease, stroke, and chronic wounds. On the other hand, excessive angiogenesis is also detrimental, and linked to conditions such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, and psoriasis. Recently, SerRS was found to play an essential role in angiogenesis through VEGFA/VEGFR2 signal pathways. The crystal structures of human SerRS, and of SerRS in complex with its potential interaction partners would provide important mechanistic understandings of a tRNA synthetase in angiogenesis regulation.