VOLTAGE-GATING MECHANISM OF POTASSIUM CHANNELS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 电压门控钾(Kv)通道(http://www.ks.uiuc.edu/Research/kvchannel/) 是存在于生命的所有三个领域的完整的膜蛋白。在一个专门的 一类动物细胞，称为可兴奋细胞--包括神经元、肌肉细胞和 内分泌细胞-Kv通道与其他阳离子通道(钠和钙)一起工作 通道)来调节细胞的电活动和信号[1]。千伏通道 激活(打开和关闭)以响应两端电势的变化 细胞膜允许K+离子被动和选择性地通过 频道。钾的传导是由电化学梯度控制的。 和细胞膜，可以达到很高的比率，同时仍然歧视 所有其他阳离子(包括较小的Na+离子)[1]。除了电信号之外 在神经系统中，Kv通道在心脏的调节中起着重要的作用。 胰岛素释放的兴奋性和调节。在人类中，这些通道的故障可能 导致神经或心血管疾病，如长QT综合征或发作性共济失调 [2]。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Voltage-gated potassium (Kv) channels (http://www.ks.uiuc.edu/Research/kvchannel/) are integral membrane proteins present in all three domains of life. In a specialized class of animal cell, known as excitable cells - including neurons, muscle cells, and endocrine cells - Kv channels work with other cation channels (sodium and calcium channels) to regulate the electrical activity and signaling of the cell [1]. Kv channels activate (open and close) in response to changes in the electrical potential across the cell membrane allowing passive and selective conduction of K+ ions through the channel. Potassium conduction is directed by the electrochemical gradient across the cell membrane and can achieve very high rates, while still discriminating against all other cations (including the smaller Na+ ions) [1]. In addition to electrical signaling in nervous systems, Kv channels play an important role in the regulation of cardiac excitability and regulation of insulin release. In humans, malfunction of these channels can result in neurological or cardiovascular diseases such as long QT syndrome or episodic ataxia [2].