TRANSCRIPTION FACTOR A, MITOCHONDRIAL

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 线粒体是负责氧化磷酸化的细胞器。氧化代谢的效率和调节对于维持不同的生理过程至关重要。影响氧化代谢的线粒体缺陷与衰老、神经变性和各种遗传性线粒体疾病有关。线粒体的功能严格依赖于线粒体基因组的表达，而线粒体基因转录是这一过程中的关键环节。我们的实验室目前正试图了解线粒体转录机制的结构生物学和生物化学，并研究其控制的核激素受体。阐明这一关键细胞过程的调节机制对许多人类疾病具有重要意义，并可能导致新的潜在治疗途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mitochondria are the organelles responsible for oxidative phosphorylation. The efficiency and regulation of oxidative metabolism is critical to sustain different physiological processes. Mitochondrial deficiencies that affect oxidative metabolism are linked to aging, neurodegeneration and a variety of genetic mitochondrial diseases. Mitochondrial function is strictly dependent on the expression of the mitochondrial genome, and mitochondrial gene transcription is a key link in this process. Our laboratory is currently trying to understand the structural biology and biochemistry of the mitochondrial transcription machinery and to study its control by nuclear hormone receptors. Elucidating the mechanisms of regulation of this key cellular process has important implications for a number of human diseases and may lead to new potential avenues for therapeutics.