EFFECTS OF EXPLOSIVE BLAST AS COMPARED TO POST-TSD ON BRAIN FUNCTION & STRUCTURE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 爆炸性爆炸致脑损伤是现代作战的一个显著特征。我们将使用复杂的大脑功能和结构测量方法，以2007年秋季从部署返回的伊拉克自由行动(OIF)国民警卫队士兵为样本，描述爆炸造成的脑损伤的特征。直接评估神经破坏的生物学措施将被用来表征爆炸相关脑损伤和创伤后精神病理学在大脑结构和功能方面的差异。为了充分描述冲击波对大脑的影响，并将它们与创伤后应激障碍区分开来，我们将对比暴露在爆炸中的士兵组和经历创伤后应激障碍的组。预计这项由国防部资助的研究可能需要长达四年的时间。 这项研究将提供一种方法，将爆炸冲击波引起的脑损伤和心理痛苦的共存情况与创伤后精神病理学分开。这项研究的结果将有助于临床医生更好地区分创伤后应激障碍和爆炸伤所致的脑损伤，增加我们对神经功能和结构方面的基本特征的了解。更好地区分这两种情况将使临床医生能够设计更合适的治疗方案。这项研究的结果将被用来为爆炸相关神经损伤后的诊断和恢复机制提供信息，以便创建使士兵恢复最大功能水平的干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Brain injury from explosive blast is a prominent feature of contemporary combat. We will use sophisticated measures of brain function and structure to characterize brain injury from explosive blasts in a sample of Operation Iraqi Freedom (OIF) National Guard soldiers who returned from deployment in the fall of 2007. Biological measures that directly assess neural disruption will be used to characterize differences in brain structure and function between blast-related brain injury and post-traumatic psychopathology. To fully characterize the effects of blast on the brain and differentiate them from post-traumatic stress disorder, we will contrast groups of soldiers exposed to blast with groups experiencing post-traumatic stress disorder. It is expected that this DoD-funded study may take up to four years. This study will provide a means for separating co-occurring conditions of brain injury and psychological distress due to explosive blast and post-traumatic psychopathology. The results of this research will help clinicians better differentiate between post-traumatic stress disorder and brain injury due to explosive blast by increasing our understanding of the essential features of the conditions in terms of neural function and structure. Better differentiation between the two conditions will allow clinicians to design more appropriate treatment protocols. Results of this research will be used to inform diagnosis and characterize mechanisms of recovery after blast-related neural injury to allow the creation of interventions that return soldiers to maximum levels of functioning.