DATA MANAGEMENT AND STATISTICS CORE

项目总结（见说明）： 数据管理和统计（DMS）核心的目标是提供数据管理和统计专业知识，这对埃默里大学阿尔茨海默病研究中心（ADRC）的研究项目和辅助研究的有序进展和成功至关重要。DSM核心将负责与ADRC相关的以下活动： 目标1。提供、管理和维护一个高质量的研究数据库，以支持埃默里大学ADRC的研究项目、核心和辅助研究;与临床核心在研究受试者的人类受试者保护管理方面合作;实施技术和实践政策和程序，以保护所有患者和对照受试者记录的机密性;监督和 管理埃默里大学研究人员与ADRC合作进行的研究项目的数据收集。 目标2.就ADRC研究的设计、实施、分析和解释提供统计咨询和合作。 目标3.与国家阿尔茨海默病协调中心（NACC）合作并共享统一数据集（UDS）数据。 我们已经开发了一个数据输入系统和该系统的标准操作程序手册，该系统允许安全有效地输入UDS数据和所有神经科患者的数据。我们计划通过采用UCSF ADRC开发的系统，与其他ADRC合作，转向基于Web的数据输入。我们已经建立了一个系统，以向ADRC调查人员提供研究对象和数据 以保护患者隐私并符合Emory IRB指南的方式。我们与其他核心密切合作，特别是临床和神经病理学核心。 我们通过核心的两名统计学家和一名流行病学家为ADRC项目和调查人员提供统计和流行病学支持。此外，核心人员进行自己的研究，这导致了过去的出版物，并将继续在新的赠款期。

PROJECT SUMMARY (See instructions): The objectives of the Data Management and Statistics (DMS) Core is to provide the data management and statistical expertise that is vital to the orderiy progress and success ofthe research projects and ancillary studies of the Emory University Alzheimer's Disease Research Center (ADRC). The DSM Core will be responsible for the following activities related to the ADRC: Aim 1. To provide, manage and maintain a high-quality research database that supports the research projects, cores, and ancillary studies of the Emory University ADRC; to cooperate with the Clinical Core in the human subjects protection administration for research subjects; to implement technological and practical policies and procedures to preserve the confidentiality of all patient and control subject records; oversee and manage the collection of data for research projects conducted by Emory investigators working with the ADRC. Aim 2. To provide statistical consulting and collaboration on the design, conduct, analysis and interpretation of ADRC research studies. Aim 3. To cooperate with and share Uniform Data Set (UDS) data with the National Alzheimer's Coordinating Center (NACC). We have developed a data entry system and a manual of standard operating procedures for this system which allows secure and valid data entry for both UDS data and data on all neurology patients. We plan to move to Web-based data entry in collaboration with other ADRCs, via adoption of a system developed by the UCSF ADRC. We have in place a system to provide research subjects and data to ADRC investigators in a manner that protects patients' confidentiality and complies with Emory IRB guidelines. We coordinate closely with other cores, in particular the Clinical and Neuropathology cores. We provide statistical and epidemiologic support to ADRC projects and investigators via two statisticians and one epidemiologist who are part of the core. Furthermore, core personnel conduct their own research, which has led to past publications and which will continue in the new grant period.