PROJECT F

项目F：信使核糖核酸加工遗传学；乔尔·H·格雷伯(杰克逊) 一个完整的基因调控模型需要了解DNA在表达的所有阶段的控制 通过信使核糖核酸到最终的蛋白质产物。对环境变化的反应，如饮食，涉及到 在激活的多个阶段表达。转录后加工差异的遗传基础， 例如选择性剪接和选择性聚腺苷酸化，仍然知之甚少。基因定义 小鼠品系，如DO和Rix，为研究基因的遗传差异提供了强有力的手段 对环境可控变化的反应的表达和调节。与合作伙伴 项目C、D和E我们将研究饮食对mRNA处理的遗传差异 正常饮食、高维生素D含量和高脂肪含量之间的差异。

Project F: Genetics of mRNA processing; Joel H. Graber (Jackson) A complete model of gene regulation requires understanding control at all stages of expression from DNA through mRNA to final protein product. Response to environmental changes, such as diet, involves changes in expression at multiple stages of activation. Genetic bases for differences in post-transcriptional processing, such as alternative splicing and alternative polyadenylation, remain poorly understood. Genetically defined strains of mice, such as the DO and RIX, provide a powerful means of investigating genetic differences in gene expression and regulation in response to controlled changes in environment. Working in collaboration with projects C, D, and E we will investigate genetic differences in mRNA processing in response to dietary variation between normal chow, high vitamin D content, and high fat content.