2013 Plant Metabolic Engineering Gordon Research Conference and Gordon Research S

描述（由申请人提供）：植物产生种类繁多的天然产物，虽然迄今为止已经表征了200，000多种植物天然产物，但这仅代表植物界中存在的化学多样性的一小部分。考虑到手性中心的多样性，用修饰取代基和选择性取代基进行修饰是可行的。 植物化合物在植物中的优势：与食草动物的相互作用，植物天然产物在人类生物化学、信号传导和生理学中具有特定靶点，以及为什么现在用于临床应用的三分之二的化合物来自与专门的植物代谢物有关的发现，这并不奇怪。从根本上理解和理解这些分类学上受限制的植物生化途径对于提高生产水平和将新的植物化合物引入药物开发管道至关重要。我们很幸运能成为研究人员，因为高通量测序的综合进步，基于质谱的代谢组学和生物信息学不再局限于少数模型（参考）植物研究生物，只包含植物王国中化学多样性的一小部分，而是被应用于广泛的“非模式”植物物种是分类学上限制的植物化学和生物化学多样性的进化储存库。为了提供一个多学科合作的发展，需要解开植物天然产物生物合成的复杂性，并推进植物代谢工程的基础和应用研究，以支持药物开发活动，我们正在请求支持2013年植物代谢工程戈登研究会议（GRC）和联合戈登研究研讨会（GRS）将于7月6日至12日举行，2013年在新罕布什尔州白色山脉的沃特维尔山谷会议中心。在这个新的GRC会议系列的第五次两年一度的会议（最初于2005年举行）中，我们预计演讲者和参与者的数量将接近160人，来自美国和国外的代表，在所有职业水平，并代表学术界，工业界，私人机构和联邦实验室的机构。协调一致的努力将继续鼓励妇女、残疾人和代表性不足群体的科学家参与。本次会议的具体目标是：1。支持全球领导者参与植物生物化学和代谢工程的不同领域，特别是与人类健康重要的植物途径有关的领域。2.促进本研究竞技场中所有职业水平所需的跨学科互动。3.为了支持研究生和博士后研究人员的参与，下一代植物代谢工程师，在戈登研究研讨会，这为他们提供了一个独特的场所，直接向他们的研究，并与他们的同行网络？

DESCRIPTION (provided by applicant): Plants produce an enormously diverse array of natural products and while more than 200,000 plant natural products have been characterized to date, this represents but a fraction of the chemical diversity present in the plant kingdom. Given the multiplicity of chiral centers, elaboration with modifying substituents and the selective advantage of plant compounds in plant: herbivore interactions, it is not surprising that plant natural products have specific targets in human biochemistry, signaling and physiology and why two-thirds of compounds now utilized in bedside applications originate from discoveries related to specialized plant metabolites. Accessing and understanding at a fundamental level these taxonomically restricted plant biochemical pathways is essential for improving production levels and bringing new plant compounds into the drug development pipeline. We are fortunate to be researchers at a time when the combined advances in high throughput sequencing, mass spectrometry based metabolomics and bioinformatics are no longer restricted to a handful of model (reference) plant research organisms that contain only a fraction of the chemical diversity in the plant kingdom and instead are being applied to a wide range of "non-model" plant species which are the evolutionary reservoir of taxonomically restricted, plant chemical and biochemical diversity. To provide a setting for the development of the multidisciplinary collaborations needed to unravel the complexity of plant natural product biosynthesis and to advance basic and applied research in plant metabolic engineering in support of drug development activities, we are requesting support for the 2013 Plant Metabolic Engineering Gordon Research Conference (GRC) and joint Gordon Research Seminar (GRS) to be held July 6-12, 2013 at the Waterville Valley conference center in the White Mountains of New Hampshire. In this fifth biennial meeting of this new GRC conference series (initially held in 2005), we expect the number of speakers and participants to approach 160 with representatives from the US and abroad, at all career levels, and representing institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will continue to encourage the participation of women, persons with disabilities, and scientists from underrepresented groups. The specific aims of this conference are: 1. To support the participation of global leaders in the different areas of plant biochemistry and metabolic engineering that specifically relate to plant pathways of importance to human health. 2. To foster the cross disciplinary interactions needed at all career levels in this research arena. 3. To support the participation of graduate students and postdoctoral researchers, the next generation of plant metabolic engineers, in the Gordon Research Seminar, which provides a unique venue for them to present their research directly to, and network with, their peers?