Developing an HIV Prevention Program for High Risk Couples

描述(由申请人提供)：在这项R34研究中，我们将开发和试点以夫妇为重点的艾滋病毒预防干预措施，针对变性人妇女和他们的男性主要伴侣。在美国，变性人女性是感染艾滋病毒的最高风险群体之一，据报道，变性人女性最频繁地与其男性主要伴侣发生无保护措施的性行为。最近，与变性人女性发生性关系的男性被确定为艾滋病毒的高危人群。目前还没有基于证据的干预措施来减少变性人妇女或MSTW中的艾滋病毒感染。我们提出了一项创新性的研究，将调整以经验支持的夫妇为重点的艾滋病毒干预措施的原则，以开发一种干预措施，以降低变性人妇女及其男性主要伴侣的艾滋病毒风险。在改编夫妻咨询材料后，我们将对60对夫妇进行以夫妇为重点的干预试验，其中包括变性人女性及其男性主要伴侣。研究结果将提供有关夫妇艾滋病毒预防干预试验的效果、可行性、可接受性和实施过程的初步数据。如果这项研究显示出初步的希望，我们将使用研究结果来支持R01应用，在随机对照试验中测试干预效果。

DESCRIPTION (provided by applicant): In this R34 research study we will develop and pilot-test a couples focused HIV prevention intervention addressing transgender women and their male primary partners. In the U.S., transgender women are among the highest-risk groups for HIV infection, and transgender women report most frequently engaging in unprotected sex with their male primary partners. Men who have sex with transgender women (MSTWs) have recently been identified as a high-risk population for HIV. Currently there are no evidence-based interventions to reduce HIV infection in transgender women or MSTWs. We propose an innovative research study that will adapt principles from empirically supported couples-focused HIV interventions in order to develop an intervention to reduce HIV risk in transgender women and their male primary partners. After adapting couples counseling materials, we will pilot test the couples-focused intervention with 60 couples comprising transgender women and their male primary partners. Findings will provide preliminary data on the effects, feasibility, acceptability, and implementation process of a couples HIV prevention intervention trial. If this research shows initial promise, we will use findings to support an R01 application to test intervention efficacy in a randomized controlled trial.