Training New Investigators in Neuroimaging and in the Neuropsychiatry of Movement

描述(由申请者提供)：申请以患者为中心的研究(K24)职业生涯中期奖的计划是为了让PI将50%的精力投入到所描述的指导和研究活动中。PI是一名获得董事会认证的神经精神病学家，在精神病学住院医师培训结束后，他完成了为期两年的运动障碍和神经成像研究。他贡献了新的神经成像方法，并将其应用于帕金森病和TS的神经精神病学方面。他目前的研究包括这两个领域的研究，但这一应用侧重于PI对抽动症(TS)的研究。这包括由NIMH和Tourette综合征协会资助的正在进行的神经成像研究，以及针对这一应用提出的新的TS成像研究。这些新的研究建立在PI过去研究的基础上，跟进了最近发表的TS研究中令人兴奋的线索，并计划与儿童神经病学和儿童精神病学的同事合作，进一步开发一个关于TS的协调研究计划。多年来，PI已经指导了40多名年轻的实习生，其中许多人是短暂的暑期或学期实习，但也有一些是长期的。在过去的三年里，PI的两名长期临床实习生(一名精神病学住院医师和一名临床神经心理学家博士后)因其实验室所做的研究和他们的整体职业潜力而获得美国神经精神病学协会的青年研究员奖。国际医学联合会现在已经确定了新的医学博士研究员和学生，他们的培训将得到加强，因为这里提议的具体指导活动将有更多的时间。该机构以充满活力的神经科学研究中心而闻名，其最近获得的CTSA赠款部分将进一步支持该提案中的培训和研究活动。该部门已承诺将PI从医学院核心精神病学助理的行政职责中解放出来，并从住院或咨询联络临床职责中解放出来，以换取K24奖项将支持的导师和以患者为导向的研究机会。简而言之，申请者的指导经验、研究贡献以及近期对TS的研究计划都在K24的适当支持下达到了完美的时刻。

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient-Oriented Research (K24) is planned to allow the PI to devote 50% effort to the mentoring and research activities described. The PI is a board-certified neuropsychiatrist who completed a two-year movement disorders and neuroimaging fellowship after psychiatry residency. He has contributed new neuroimaging methods and applied them to neuropsychiatric aspects of Parkinson disease and TS. His current research includes studies in both these areas, but this application focuses on the PI's research into Tourette syndrome (TS). This includes ongoing neuroimaging studies funded by NIMH and the Tourette Syndrome Association, and new TS imaging studies are proposed for this application. The new studies build on the PI's past research, follow up on exciting leads from recently published TS research, and are planned to further develop a coordinated research program on TS in collaboration with colleagues from child neurology and child psychiatry. The PI has mentored over 40 young trainees over the years, many of them for brief summer or semester stints, but some for longer terms. In the past 3 years, 2 of the PI's longer-term clinical trainees (a psychiatry resident and a clinical neuropsychologist post-doc) have won the American Neuropsychiatric Association's Young Investigator Award for research done in his lab and for their overall career potential. The PI has now identified new M.D. research fellows and students whose training will be enhanced by additional time for the specific mentorship activities proposed herein. The institution is well known as a vibrant center for neuroscience research, and its recently awarded CTSA grant components will further support the training and research activities in this proposal. The department has committed to free the PI from his administrative duties with the medical school core psychiatry clerkship and from inpatient or consultation-liaison clinical duties in exchange for the mentorship and patient-oriented research opportunities that this K24 award will support. In short, the applicant's mentoring experience, research contributions, and near-future plans for research on TS have all arrived at the perfect moment for appropriate support from the K24.