Administrative Core

说明）： 行政核心的基础设施将有助于确保中心的成功，并加快 其发现。核心将提供广泛的组织、时间安排、机构合规和财务 控制整个P50活动，并与NIH协调P50活动。核心A也将是 负责确保中心的项目保持以病人为中心的理念，它将管理和 支持该中心的浓缩和试点部分。核心A有以下三个具体目标： 具体目标1：提供中心范围内的沟通、组织和协调 沟通、有效传递和整合不同意见对我们的成功至关重要。 使命。因此，核心A virill与所有其他项目和核心进行交互，以组织、跟踪和更新 患者分析的进展，包括及时将数据从一个项目转移到另一个项目，并及时通知 可能影响口译的问题。核心还将跟踪和传达 患者关于选择参加或退出研究的意愿。 具体目标2：控制中心的“时钟” 核心将启动每18个月对每位患者外显子组数据的强制性重新分析， 包括自初步分析以来在该领域的发现。此外，核心将管理和 使用自动化软件跟踪“20周”时间轴，这是中心识别患者的目标 返回结果，包括排序，管道分析，讨论，并纳入功能 分析。 具体目标3：管理试点和可行性计划的提案征集和评估， 支持它和丰富计划 参考（参见说明）： 行政核心的基础设施将有助于确保中心的成功， 组织、时间安排、机构合规和财务控制， 其他资助中心在杜克和其他地方，通过确保该中心的项目保持以病人为中心， 理念，并通过支持丰富和试点计划。

Instoictions): The Administrative Core's infrastructure will help ensure the Center's success and accelerate application of its discoveries. The Core will provide broad organization, scheduling, institutional compliance and financial control across the P50 activities and also coordinate P50 activities with the NIH. Core A also will be responsible for ensuring the Center's projects retain a patient-centric philosophy, and it will manage and support the Enrichment and Pilot components of the Center. Core A has the following three specific aims: SPECIFIC AIM 1: Provide Center-wide communication, organization, and coordination Communication, efficient transfer and integration of diverse opinions are critical to the success of our mission. Therefore, Core A virill interact with all other Projects and Cores to organize, track, and update progress of patient analyses, including the timely transfer of data from project to project and of notifications regarding items that might affect interpretation. The Core will also track and communicate changes in patients' wishes with regard to opting in or out of the study. SPECIFIC AIM 2: Control the Center "clock" The Core will activate a mandatory re-analysis of exome data for each patient every 18 months to incorporate discoveries made in the field since the initial analysis. In addition, the Core will manage and track, using automated software, the "20-week" timeline that is the Center's goal for identification of a patient to return of results, including sequencing, pipeline analysis, discussion, and incorporation of functional analyses. SPECIFIC AIM 3: Manage proposal solicitation and evaluation for the Pilot & Feasibility Program and support both it and the Enrichment Program RElpoundVANCE (See instmctions): The Administrative Core's infrastructure will help ensure the Center's success by providing broad organization, scheduling, institutional compliance and financial control, by coordinating interactions with other funded centers at Duke and elsewhere, by ensuring the Center's projects retain a patient-centric philosophy, and by supporting the Enrichment and Pilot Programs.