TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS TRAINING (51)

描述（由申请人提供）：我们的目标是在加州洛杉矶大学（UCLA）培养传染病医学博士或医学博士/博士博士后研究员，从事艾滋病和慢性病毒发病机制的转化研究。随着病毒性疾病（如HIV-1和病毒性丙型肝炎）的全球疾病负担日益增加，以及基础科研的增加，开发成功疗法和疫苗的关键瓶颈是转化研究。因此，迫切需要合格的医生科学家研究人员谁可以从板凳上工作到床边。 鉴于加州大学洛杉矶分校在翻译/基础HIV-1研究和基础病毒学研究的整体实力，我们提出了一个培训计划，主要集中在HIV-1，研究员有机会追求其他病毒的翻译发病机制研究。我们已经召集了一批经过精心挑选的教职员工，作为潜在的导师，跨越加州大学洛杉矶分校的几个部门。将鼓励学员充分利用参与基础科学和临床教师之间的众多合作，以创造独特的转化研究机会。研究导师有积极的IRB协议，招募受试者进行HIV和HCV发病机制的研究，积极参与新型抗病毒疗法的人体试验，并正在研究HIV发病机制的几乎所有方面。许多教师导师也在研究HCV复制和持久性的基本方面。 我们的计划将支持MD学员（导致博士）或MD/博士学员（寻求正式的博士后培训）作为他们的传染病专科培训的一部分。我们将寻求一个合格的培训生，每年最多3名学员在该计划在任何时候。我们的计划旨在为学员提供重要的受保护的研究时间，以便他们可以发展独立的研究兴趣并获得独立的资金。该培训计划的最终目标是让所有学员最终成为独立调查员。 相关性：这项培训补助金将支持新的医生科学家的发展，由于我们的培训计划，将增加研究艾滋病和慢性病毒发病机制的合格人员的数量。科学工作者队伍的增加将加快发现新方法的克里思，以对抗艾滋病和其他慢性病毒感染，如丙型肝炎。

DESCRIPTION (provided by applicant): Our goal is to train infectious disease MD or MD/PhD postdoctoral fellows at University of California Los Angeles (UCLA) in translational research in AIDS and chronic viral pathogenesis. With an increasing global disease burden of viral diseases (such as HIV-1 and viral hepatitis C) and increasing basic scientific research, a key bottleneck for developing successful therapies and vaccines is translational research. There is therefore a pressing need for qualified physician-scientist researchers who can work from bench to bedside. Given the overall strength of UCLA in translational/basic HIV-1 research and basic virology research, we propose a training program that is predominately focused on HIV-1, with opportunities for fellows to pursue translational pathogenesis studies on other viruses as well. We have assembled a highly selected group of faculty members to serve as potential mentors, spanning several UCLA departments. Trainees will be encouraged to take full advantage of the numerous collaborations between participating basic science and clinical faculty in order to create unique translational research opportunities. Research mentors have active IRB protocols to recruit subjects for the study of HIV and HCV pathogenesis, are actively involved with human trials for novel antiviral therapeutics, and are studying virtually all aspects of HIV pathogenesis. Many faculty mentors are also studying fundamental aspects of HCV replication and persistence. Our program will support MD trainees (leading to a PhD) or MD/PhD trainees (seeking formal postdoctoral training) as part of their Infectious Diseases subspecialty training. We will be seeking one well-qualified trainee each year with maximum 3 trainees in the program at any time. Our program is structured to provide trainees with significant protected research time so that they may develop independent research interests and secure independent funding. The ultimate goal of this training program is for all trainees to ultimately succeed as independent investigators. RELEVANCE: This training grant will support the development of new physician-scientists, and as a result of our training program there will be an increase in the number of well-qualified individuals studying AIDS and chronic viral pathogenesis. This addition to the scientific workforce will increase the tempo of discovery of new approaches to combat AIDS and other chronic viral infections such as Hepatitis C.