Depression Subtypes: Cognition, Emotion, Neurophysiology

描述（由申请人提供）：最近的抑郁症模型已经概述了抑郁症中边缘、情绪处理和显著性脑区之间的关系，其中假设额顶叶、执行控制脑区不能调节这些边缘区。然而，尽管有这些理论主张，在功能成像过程中仍然缺乏认知和情感挑战研究，以评估抑郁症中这些被破坏的情感处理和执行调节回路。此外，复杂的抑郁症研究是围绕抑郁症作为单一或异模态实体，不同的临床亚型模型的争议。目前的建议对比性能和激活在功能磁共振成像，而受试者完成情绪处理和执行功能的任务，以确定参与这些过程的大脑回路。此外，焦虑症状的类型和严重程度在提案中使用维度方法进行了进一步探讨。主要研究者（PI）Scott Langenecker博士，已建议开展这项研究的背景下，继续教育活动，旨在发展专业知识的统计模型，功能性磁共振成像物理学，抑郁症亚型。在他的导师乔恩-卡尔·祖别塔医学博士的帮助下，哲学博士、和他的共同导师道格·诺尔博士Langenecker博士召集了广泛的研究人员和统计学家来协助这项奋进。这个K奖允许改变研究方向，从健康老龄化的功能成像工作，以解决抑郁症的执行功能和情绪调节。专业知识是必要的，以充分利用功能磁共振成像来了解抑郁症的神经生理学，包括认知和情感的挑战。导师和协作关系提出了一些特殊的研究人员在抑郁症和功能成像。短期目标是在完成拟议的研究的同时扩大Pis的知识基础。长期目标是提高抑郁症诊断亚型的准确性和可靠性，了解抑郁症情绪的调节和经验方面之间的关系，并利用这些机制来提高治疗匹配范例。充分的理论背景，严谨的方法，和强大的初步数据支持这个项目的假设和目标。R 01提案计划在拟议项目的第三年年底提出，作为Pis独立研究生涯发展的跳板。密歇根大学抑郁症中心为这项研究提供了一个出色的媒介，PI和他的团队可以使用一组出色的抑郁症研究人员。

DESCRIPTION (provided by applicant): Recent models of depression have outlined a relationship between limbic, emotion processing and salience brain regions in depression, with the hypothesis that fronto-parietal, executive control brain regions are unable to regulate these limbic regions. Yet, despite these theoretical claims, there remains a paucity of cognitive and emotion challenge studies during functional imaging to assess these proposed disrupted emotion-processing and executive-regulatory circuits in depression. Further, complicating depression research is the controversy surrounding the model of depression as unitary or heteromodal entities, with different clinical subtypes. The current proposal contrasts performance and activation during fMRI while subjects complete an emotion processing and an executive functioning task to determine brain circuits involved in these processes. In addition, type and severity of anxiety symptoms is further explored in the proposal using a dimensional approach. The principal investigator (PI), Scott Langenecker, Ph.D., has proposed to carry out this research in the context of continuing education activities directed towards developing expertise in statistical models, functional MRI physics, and depression subtypes. With the assistance of his mentor, Jon-Kar Zubieta, M.D., Ph.D., and his co-mentor, Doug Noll, Ph.D., Dr. Langenecker has assembled a broad range of researchers and statisticians to assist in this endeavor. This K award allows for a change in research direction, from functional imaging work in healthy aging, to address executive functioning and emotion regulation in depression. Expertise is necessary to fully exploit functional MRI to understand the neurophysiology of depression, including cognitive and emotional challenges. Mentorship and collaborative relationships are proposed with a number of exceptional researchers in depression and functional imaging. Short-term goals address expansion of the Pis knowledge base, while completing the proposed study. Long term goals address increasing diagnostic subtyping accuracy and reliability for depression, understanding the relationship between regulatory and experiential aspects of emotion in depression, and using these mechanisms to enhance treatment matching paradigms. Sufficient theoretical background, methodological rigor, and strong preliminary data support the hypotheses and aims of this project. An R01 proposal is planned for the end of year three of the proposed project, as a springboard to the development of the Pis independent research career. The University of Michigan Depression Center provides an outstanding medium for pursuing this study, with an exceptional cohort of depression researchers available to the PI and his assembled team.