Electronic system for wireless monitoring of patient medication adherence

描述(由申请人提供)：我们的目标是为患者和医生提供一个有效的新工具，以提高患者对处方药方案的依从性(又名依从性)。患者依从性差会降低患者的健康，增加可预防的发病率，并导致本可避免的医疗成本。即使在受监控的临床试验中，依从性往往很差，改善依从性的干预措施成本高昂，结果喜忧参半。对于一些患者群体，如艾滋病毒携带者，不良的服药依从性可能会导致健康状况迅速下降，增加病毒对抗生素的耐药性，并导致过早死亡。我们提出了一种无线剂量报告系统，将为医生和照顾者提供及时准确的用药提醒和遵从性报告。该系统将被设计为利用蓝牙和手机系统等无线技术向患者监视器提供剂量数据，而患者的费用很低。这项工作的结果将是一种连接到标准药物容器上的电子电路，该容器可以将剂量数据传输到患者的智能手机。移动电话应用程序将收集剂量数据，并将该信息实时传输到监测点。我们公司有剂量提醒和记录电路，可以安装在标准的药物容器上，而不会干扰容器的包装或内容物。在给药时间，一盏灯会提示患者服药。该电路记录所有给药事件的日期和时间，该日期和时间是通过设计用于区分给药事件和容器的附带移动之间的差别的算法来确定的。我们将扩展DoseCue电路的功能，以包括通过蓝牙通信将存储在电路存储器中的配药数据无线传输到智能手机。安装在患者手机上的移动应用程序将在特定时间从电路收集剂量数据，并将信息传输到中央处理点，以便根据需要进行实时干预。该系统将进行测试，以验证易用性、通过手机网络无线传输数据的有效性以及患者剂量数据的准确性。该系统将患者的家庭用药剂量实时反馈给他们的医生、护理员或其他授权人员，而无需患者采取行动(例如通过USB连接到计算机)。通过在患者没有按处方服药时提供实时警告，患者监测器可以在负面健康影响发生之前进行干预。一个完整的无线合规系统将有利于患者的健康并降低医疗成本。 与公共健康相关：不良的用药剂量会导致患者健康下降，并给医疗保健系统造成不必要的负担。DoseCue移动系统提供了一种简单、直接的方法来提供对患者剂量行为的实时监督。在患者剂量较低时进行干预的能力可以直接改善治疗结果，防止严重的健康问题，同时降低高危患者的医疗成本。

DESCRIPTION (provided by applicant): Our objective is to provide patients and physicians with an effective new tool to increase patient compliance (aka adherence) to prescription drug regimens. Poor patient compliance diminishes patients' health, increases preventable morbidity, and results in avoidable healthcare costs. Even in monitored clinical trials, compliance is often poor and interventions to improve compliance are expensive and have mixed results. For some patient populations, like those with HIV, poor medication compliance can result in a rapid decline in health, increased resistance of the virus to antibiotics, and premature death. We propose a wireless dosing reporting system that will provide physicians and caregivers timely and accurate medication reminder and compliance reporting. The system will be designed to take advantage of wireless technologies like Bluetooth and the cellular phone system to provide dosing data to a patient monitor at little expense to the patient. The outcome of the work will be an electronic circuit that attaches to a standard medication container that can transmit dosing data to a patients' smartphone. A mobile phone application will collect the dosing data and transmit that information to a monitoring site in real time. Our company has dose reminding and recording circuitry that attaches to standard medication containers without interfering with the packaging or contents of the container. At dose time, a light prompts the patient to take their medication. The circuitry records the date and time of all dosing events as determined through algorithms designed to distinguish the difference between a dosing event and incidental movement of the container. We will extend the capability of the DoseCue circuitry to include wireless transmission of the dosing data stored in the circuitry's memory to a smartphone via Bluetooth communication. A mobile application installed on patients' phones will collect the dosing data from the circuitry at specific times and transmit the information to a central processing point, allowing for intervention in real time as needed. The system will be tested to verify ease of use, effectiveness in transmitting data wirelessly across the cell phone network, and accuracy of patient dosing data. The system provides real-time feedback of patients' home medication dosing to their doctor, caregiver, or other authorized person without requiring action by the patient (such as connecting to a computer via USB). By providing real-time warnings when a patient is not taking their medication as prescribed, a patient monitor can intervene before negative health effects occur. A completed wireless compliance system will benefit patient health and reduce healthcare costs. PUBLIC HEALTH RELEVANCE: Poor medication dosing results in a decline in patient health and creates an unnecessary burden to the healthcare system. The DoseCue Mobile system provides a simple, direct method for providing real-time oversight of patient dosing behavior. The ability to intervene when patient dosing is poor can directly improve treatment outcomes and prevent serious health problems while reducing healthcare costs for high risk patients.