Forumlation Development and Selection of DuoGels and Smart Suppositories

项目总结（见说明）： 由于接受性肛交的实践并不限于与男性发生性关系的男性（MSM），并且有明确的证据表明在同一性行为中接受性阴道性交和肛交，因此开发适合直肠和阴道应用的杀微生物剂制剂是有充分理由的。双室杀微生物剂配方将降低为同时进行肛交和阴道性交的妇女维持单独剂型的复杂性。随着IQP-0528/TFV复方阴道凝胶的开发前景看好，将在项目1中利用现有凝胶制剂开发一种新型阴道和直肠双重凝胶（DuoGel）。此外，为了直接解决使用者可接受性的潜在问题以及双室杀微生物剂产品中阴道和直肠之间的生理差异，

PROJECT SUMMARY (See instructions): As the practice of receptive anal intercourse is not limited to men who have sex with men (MSM), and there is clear evidence of both receptive vaginal and anal intercourse in the same sexual act, there is a strong rationale for the development of a microbicide formulation that is suitable for both rectal and vaginal application. A dual compartment microbicide formulation will reduce the complexity of maintaining separate dosage forms for women who engage in both anal and vaginal sex. With the promising development of the IQP-0528/TFV combination vaginal gel, a novel dual vaginal and rectal gel (DuoGel) will be developed in Project 1 from the preexisting gel formulation. In addition, to directly address potential issues of user acceptability and physiological differences between the vagina and rectum in a dual chamber microbicide product, a