Enhancing Core Animal Facilities to Promote Biosecurity and Biosafety

描述（由申请人提供）：本提案概述旨在提高科罗拉多州立大学（画家中心）主要集中动物设施的生物安全和生物遏制能力。具体而言，该提案要求资金用于：（1）收购一个超大型（36“W x 62“H x 73“D）用于笼清洗设施的散装灭菌器，以替换使用时间超过20年的明显较小的机器（24“宽x 36“高x 48“深）不再可用;以及（2）翻新动物设施的专用翼的入口/出口区域，目前在动物生物安全3级隔离区饲养豚鼠，用于分枝杆菌疫苗和治疗研究。该提案将为来自12个学术部门的96名确定的主要研究人员提供服务，目前的校外资助超过1.305亿美元，其中包括世界知名的分枝杆菌研究实验室的近12名教职员工（目前总资金为5480万美元）。CSU在2010财年的研究投资组合达到创纪录的3.03亿美元，比过去5年增长了50%。由于该大学的重点是传染病，癌症和其他生物医学研究计划，该项目将加强对人类健康有益的大量研究。与支持开发和维护最先进的动物设施的良好记录一致，研究副总裁已承诺提供资金用于改造笼舍，以适应本申请中要求的高压灭菌器安装。机构生物安全干事还大力支持本提案中概述的各项目标，这些目标将使生物安保得到重大加强。施工将严格考虑由LEED认证的设施专业项目经理指导的可持续概念。

DESCRIPTION (provided by applicant): This proposal outlines aims to enhance the biosecurity and biocontainment capacity of the primary centralized animal facility at Colorado State University (Painter Center). Specifically, the proposal requests funds to: (1) acquire an oversized (36"W x 62"H x 73"D) bulk sterilizer for the cagewash facility to replace a >20 year old significantly smaller machine (24"W x 36"H x 48"D) that is no longer serviceable; and, (2) renovate the entry/exit area of a specialized wing of the animal facility, currently housing guinea pigs at Animal Biosafety Level 3 containment for Mycobacterial vaccine and therapeutic studies. This proposal will serve 96 identified principal investigators from twelve academic departments with over $130.5M in current extramural grant support, including nearly a dozen faculty member of the world-renowned Mycobacterial Research Laboratories ($54.8M total current funding). CSU recorded a record $303M research portfolio in FY10, an increase of 50% over the past 5 years. Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research has committed funds for renovation of the cagewash to accommodate the autoclave installation requested in this application. The Institutional Biosafety Officer also strongly supports the aims outlined in this proposal that will allow significant biosecurity enhancements to proceed. Construction will be managed with strict consideration of sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.