Hypertension Training Grant

描述(由申请者提供)：这个高血压长期项目的总体目标仍然是培养高度敬业和有才华的年轻研究人员，他们能够在高血压领域以及与这种常见疾病相关的疾病和器官方面进行高质量的生物医学研究。我们专注于为从事学术研究的博士后研究人员做准备。我们增加了新的教员，以扩大到一个由14名科学家组成的项目学院，并在新的NIH资助的中心补助金方面，超越了加州大学圣迭戈分校的限制，获得了新的合作资金来源。新增的教员组成了较年轻但资金充足的教员，他们在翻译和临床研究方面具有特定的天赋和成就。我们还指定了一组中级初级教职员工，以增加指导过程。我们还得到了加州大学圣迭戈分校医学院和院系层面的额外机构支持。加州大学圣迭戈分校最近还获得了美国国立卫生研究院临床和翻译科学奖。该计划将提供一系列的兴趣、技能和方法，从基础研究、翻译研究到临床研究。我们增加了国际公认的外部咨询委员会的监督，并任命了一名内部副项目主任。我们还增加了一门职业发展课程，以帮助学员掌握学术技能，包括选择最初的教师职位。高血压的最终共同途径是一个复杂的、多因素的过程，它不仅产生终末器官损害，而且还由器官过程产生，例如交感神经系统、代谢和内分泌因素，并受到肾脏反应的严重影响。这是一项竞争性的续展申请，成功地培训了在过去的赠款资助周期中以较高比率被安排在学术职位上的年轻调查人员。我们已经决定取消博士后培训计划，并将重点放在博士后培训上，该计划多年来在医学博士和博士学位的学术安置方面取得了出色的记录。博士后实习生是从一批优秀的合格申请者中挑选出来的，这些申请者来自竞争性的肾病学-高血压奖学金计划，并从该计划学院成员的申请中挑选出来。我们要求将博士后职位从每年4个增加到5个。招聘代表新学科的教员加强了这一计划。我们强调了招聘的多样性，并强调了正式的课程要求和机会，包括关于适当开展道德研究活动的课程。圣地亚哥是一个丰富的研究环境，在基础研究、翻译研究和临床研究方面提供了广泛的教育机会。因此，这一培训计划已经扩大，并在将受训人员安置在美国各地的学术生涯方面取得了重大成功，并继续提供与高血压广泛领域相关的各种研究学科和调查领域。

DESCRIPTION (provided by applicant): The overall goals of this longstanding program in Hypertension remain the training of highly dedicated and talented young investigators capable of performing high quality biomedical research in the area of hypertension and the diseases and organs associated with this common medical condition. We focus upon the preparation of postdoctoral investigators for a career in academic research. We have added new faculty to expand to a Program Faculty of 14 scientists and new sources of cooperative funding extending beyond the confines of UCSD in terms of new NIH funded Center Grants. The additional faculty constitute younger but well funded faculty with specific talents and accomplishments in translational and clinical research. We also designate a group of secondary junior faculty that add to the mentoring process. We have additional institutional support by UCSD at the School of Medicine and Department levels. UCSD has also been awarded a recent NIH Clinical and Translational Science Award. The program will provide a range of interests, skills and approaches, ranging from basic, translational to clinical research. We have added oversight with an internationally recognized External Advisory Committee and appointment of an internal Associate Program Director. We have also added a Career Development course to assist trainees in academic skills including selection of initial faculty appointment. The final common pathway of hypertension is a complex, multifactorial process which not only produces end organ damage, but hypertension is also generated by organ processes, e.g., sympathetic nervous system, metabolic and endocrine factors, and, critically influenced by the response of the kidney. This is a competitive continuation application which has successfully trained young investigators that have been placed in academic positions at a high rate over the past cycle of grant funding. We have decided to eliminate the predoctoral training program and focus upon postdoctoral training, a program that has enjoyed outstanding record of academic placement of M.D.s and Ph.D.s over many years. Postdoctoral trainees are selected from an excellent pool of well qualified applicants from the competitive Nephrology- Hypertension fellowship program and from applications to members of the Program Faculty. We are requesting an increase in postdoctoral positions from 4 to 5 per year. The recruitment of faculty representing new disciplines have strengthened the program. We have emphasized the diversity of recruitments and have emphasized the formal coursework requirements and opportunities including courses on the proper conduct of ethical research activities. San Diego is a rich research environment and provides a wide spectrum of educational opportunities in basic, translational and clinical investigation. Thus, this training program has been expanded and has enjoyed major success in placing trainees in academic careers throughout the USA and continues to provide a wide variety of research disciplines and fields of investigation pertinent to the broad area of hypertension.