2013 Cell Biology of Megakaryocytes and Platelets GRC & GRS

描述（由申请人提供）：异常的血小板生成和血栓形成导致一系列血液学和心血管疾病，因此，需要持续的研究和教育努力。关于巨核细胞和血小板细胞生物学的戈登研究会议（GRC）是专注于巨核细胞（mk）及其血小板生物学的首要科学会议。这将是第五次两年一次的会议，将两组具有互补目标和兴趣的科学家聚集在一起。我们的会议将从控制巨核生成和血小板生成的过程开始，包括从诱导多能干细胞和胚胎干细胞，转向研究这些过程的新计算和筛选方法，过渡到细胞骨架背景下这些细胞的细胞生物学，然后是新发现的mk和血小板的信号，炎症和免疫功能。这个计划随后顺利地引导到一个以MK和血小板病理学相关发现为中心的会议。此外，还有一个完整的会议专门介绍热点话题，从提交的摘要中选择。计划中的会议有几个创新方面，包括1。这些会议涵盖了控制MK和血小板发育和功能的同一集群过程，因此，允许具有重叠兴趣的两个受众趋同，进一步增加了观点的交流；2. 转化潜力在一个名为：从工作台到床边的新会议和会谈中得到说明，例如与骨髓增生性肿瘤相关的血小板增多症的新治疗选择；3. 几届会议强调多学科方法；和4。第一次纳入题为：打破MK和血小板生物学范式的会议提供了学习和讨论挑战该领域旧概念的新范式的机会。2013年会议保留戈登研究研讨会（GRS）非常重要。这个场地鼓励有前途的学员更多地参与到项目中，并可能被鼓励继续发展MK和血小板生物学的职业生涯。GRS计划的一个新方面涉及到MK/血小板生物学发现的历史概述。学员提交的摘要将由评审小组评分，并选出进行口头报告，其中一些也将在GRC的“热点话题”下进行报告。与调查人员的圆桌讨论将提供与学术界和制药公司的职业有关的指导。综上所述，我们相信计划中的GRC/GRS代表了我们学科的科学前沿，并密切关注指导。GRS/GRC会议分别于2013年3月9日至10日和10日至15日在位于墨西哥湾的德克萨斯州加尔维斯顿岛历史悠久的加尔维斯酒店举行。拥有独特的宽阔海滩和岛上及附近众多景点，这将是一个令人兴奋和难忘的场所，为所有与会者。

DESCRIPTION (provided by applicant): Abnormal thrombopoiesis and thrombosis contribute to an array of hematological and cardiovascular pathologies, thus, requiring continued research and educational efforts. The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them. This will be the 5th biennial meeting that brings together two groups of scientists with complimentary goals and interests. Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in MKs and platelets. This plan then leads smoothly to a session centered on discoveries related to MK and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected from submitted abstracts. There are several innovative aspects to the planned meeting, including 1. The sessions cover within the same cluster processes that govern MK and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives; 2. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm; 3. Emphasis on multidisciplinary approaches is exemplified in several sessions; and 4. Inclusion, for the first time, of a session titled: Breaking Paradigms in MK and Platelet Biolog provides opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. The retention of the Gordon Research Seminar (GRS) for the 2013 meeting is important. This venue encourages promising trainees to participate more visibly in the program and possibly be encouraged to continue and develop a career in MK and platelet biology. A novel aspect in the GRS plan involves a talk on a historical overview of discovery in MK/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies. Taken together, we believe that the planned GRC/GRS represent the Frontiers of Science for our discipline, with keen attention to mentoring. The GRS/GRC meetings take place from March 9-10th and 10-15th, 2013, respectively, at the historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees.