FASEB SRC on Proteases in Hemostasis and Vascular Biology

描述(由申请者提供)：本申请请求部分支持由美国实验生物学学会联合会(FASE B)夏季研究会议项目主办的“止血和血管生物学中的蛋白酶”会议。这次会议将是自1992年以来每两年举行一次的系列会议中的第11次，定于2013年6月2日至7日在巴哈马拿骚的FASEB夏季会议地点举行。会议的重点已经从最初致力于凝血酶的结构和功能研究，演变到止血和血管生物学中更广泛的蛋白酶领域。人们对这一领域的兴趣格外浓厚，基于对蛋白酶及其受体、底物和抑制物在止血、血管细胞信号、屏障功能、胚胎发育、细菌毒力/宿主防御以及炎症性疾病(包括心血管疾病和神经炎性疾病)中的作用的新见解，研究活动正在加速。这一独特的会议在蛋白酶和血管生物学领域确立了自己的地位，并因一贯强调由具有不同专业知识和广泛人口统计学特征的研究人员进行的未发表的、尖端的基础和翻译研究而享有国际声誉。这次会议通常会聚集一批首屈一指的知名研究人员、杰出的年轻研究人员和有天赋的实习生，进行亲密、平衡、高度互动和富有成效的科学交流。在血管生物学中的蛋白水解酶领域的一些最重要的最新成就在本系列的前几次会议上首次亮相。已同意参加的受邀发言者和讨论领导人名单令人印象深刻，其中包括该领域的顶级调查人员。这些与会者将增强环境对所有与会者的刺激性质，特别是初级调查人员和受训人员。与以往的会议一样，组织者的优先事项是促进妇女和少数民族参与项目，并便利初级教师、学生、博士后研究员和肢体残疾个人参加。该计划目前包括一次主旨演讲和8场会议，专门讨论：1)蛋白酶结构、功能和调节；2)血小板粘附性；3)纤维蛋白(原)(溶解)；4)血小板信号；5)von Willebrand因子、TTP和蛋白酶；6)宿主防御中的蛋白酶和抑制物；7)O‘Mics：基因组学/蛋白质组学/变性/血液学；以及8)组织因子。

DESCRIPTION (provided by applicant): This application requests partial support for the "Proteases in Hemostasis and Vascular Biology" conference to be held under the auspices of the Summer Research Conference program of the Federation of American Societies for Experimental Biology (FASEB). This meeting will be the 11th in a series that has been held biennially since 1992 and is scheduled to be held at the FASEB summer conference site in Nassau, Bahamas on June 2-7, 2013. The focus of the meeting has evolved from one originally devoted to structure-function studies of thrombin into the broader arena of proteases in hemostasis and vascular biology. Interest in this area has been exceptionally strong and research activity is accelerating based on new insights on the role of proteases and their receptors, substrates and inhibitors in hemostasis, vascular cell signaling, barrier function, embryonic development, bacterial virulence/host defense, and inflammatory diseases, including cardiovascular disease and neuroinflammatory disease. This unique conference has established itself in the field of proteases and vascular biology and enjoys an international reputation for consistently emphasizing unpublished, cutting- edge basic and translational research by investigators with diverse expertise and broad demographics. The meeting has routinely drawn together a powerful mix of premiere established investigators, outstanding young investigators and gifted trainees for intimate, balanced, highly-interactive and productive scientific exchanges. Some of the most important recent achievements in the area of proteases in vascular biology were first unveiled at previous conferences in this series. The roster of invited speakers and discussion leaders who have already agreed to participate is impressive and include top investigators in the field. These attendees will enhance the stimulating nature of the environment for all attendees and especially junior investigators and trainees. As in past conferences, it is a priority of the organizers to promote program participation of women and minorities, and facilitate attendance by junior faculty, students, postdoctoral fellows and individuals with physical disabilities. The program currently includes a keynote address and 8 sessions devoted to: 1) Protease structure, function and regulation; 2) Platelet adhesion; 3) Fibrin(ogen)(olysis); 4) Platelet signaling; 5) von Willebrand Factor, TTP and proteases; 6) Proteases and inhibitors in host defense; 7) The O'Mics: Genomics/proteomics/degradomics/bloodomics; and, 8) Tissue Factor.