Fundamental Mechanobiology of Tumor Progression

PS-OC计划的目标是共同推进我们对物理定律和原则的理解，这些定律和原则塑造和管理癌症的出现及其在所有尺度上的行为。PS-OC将汇集来自物理学，癌症生物学，物理化学，数学和工程领域的专家团队，以组装和开发使团队研究融合所需的基础设施，能力，研究计划和网络。物理科学和癌症生物学的结合PS-OC将单独或共同支持和培育新的跨学科环境和研究：（1）发起和测试新的，非传统的基于物理科学的方法来理解和控制癌症;（2）生成正交物理测量集并将其与现有的癌症知识相结合;和（3）发展和评估理论物理方法，以提供全面和动态的癌症图片。最终，通过协调的，替代的，跨网络的开发和测试创新的，也许是非传统的，癌症过程的方法，PS-OC将催化和产生新的知识体系和癌症研究领域，确定和定义在癌症过程中的各个层面上运行的关键方面“物理，化学和工程”。我们正在汇集来自物理和生命科学的跨部门调查人员参加该中心。这包括五个湾区组织，这些组织在物理科学，工程和癌症研究和治疗方面具有全球公认的长期能力和兴趣。我们还从两家外部机构招募了临床研究人员，以补充现有的专业知识，并扩大我们项目的翻译范围。

The goal of the PS-OC initiative is to collectively advance our understanding of the physical laws and principles that shape and govern the emergence of cancer and its behavior at ail scales. The PS-OCs will bring together expert teams from the fields of physics, cancer biology, physical chemistry, mathematics, and engineering to assemble and develop the infrastructure, capabilities, research programs, and the Network required to enable team research converging. the physical sciences with cancer biology. PS-OCs, individually and together, will support and nurture a new trans-disciplinary environment and research that: (1) originates and tests novel, non-traditional physical-sciences based approaches to understanding and controlling cancer; (2) generates orthogonal sets of physical measurements and integrates them with existing knowledge of cancer; and (3) develops and evaluates theoretical physics approaches to provide a comprehensive and dynamic picture of cancer. Ultimately, through coordinated, alternative, trans-Network development and testing of innovative, perhaps non-traditional, approaches to cancer processes, PS-OCs will catalyze and generate new bodies of knowledge and fields of cancer study that identify and define the critical aspects "physics, chemistry, and engineering" that operate at all levels in cancer processes. We are bringing together a cross section of investigators from the Physical and Life Sciences to participate in the center. This includes five Bay Area organizations with globally recognized and long-standing capabilities and interests in the physical sciences, engineering, and cancer research and treatment. We have also recruited clinical investigators from 2 outside institutions to compliment existing expertise and to extend the translational scope of our projects.