Biological Bases of Drug-Seeking Behavior

描述（由申请人提供）：该博士前和博士后培训计划支持能够在分子到认知/临床的水平上进行临床前研究的专家的培训，这些研究涉及药物寻求行为的发展，维持和消除的生物学机制。俄勒冈州健康与科学大学的32名研究生教师担任博士后研究员和博士生导师。被录取进入行为神经科学、神经科学、生理学和药理学或生物化学基础科学研究生课程的学生。主要研究领域分为四个层次。一些教师主要在细胞/分子水平上工作，使用分子生物学，细胞生物学和电子显微镜技术。其他教师的工作主要在生理，生化和药理学系统的水平，使用受体结合，放射自显影，体内微透析和伏安法，和电生理技术，和一些工作主要在行为药理学和药物遗传学，使用行为测试，静脉药物自我管理，定量遗传学和遗传图谱，以及计算机建模技术。最后，一些教师与人类受试者一起工作，使用认知测试和各种成像技术。广泛的现有教师合作领域包括：多巴胺能系统的研究，从分子生物学到行为;药物反应的遗传决定因素的广泛研究，从分子到统计基因图谱的各个层面;以及对药物反应的学习和非学习决定因素的研究，特别是其奖励效应和药物自我管理。正在积极调查所有主要滥用药物类别的敏感性、耐受性和依赖性/戒断现象。培训包括基础科学的坚实课程基础，滥用药物的具体药理学培训，以及广泛和持续参与研究。

DESCRIPTION (provided by applicant): This program for pre- and post-doctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Thirty-two members of the graduate faculty of the Oregon Health & Science University serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or biochemistry. Major research areas represent four levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, cell biological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and electrophysiological techniques, and some work primarily in behavioral pharmacology and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modeling techniques. Finally, some faculty work with human subjects, using cognitive testing and a variety of imaging techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self- administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research.