The Bone Marrow Niche and Leukemia: Impact of Drugs, Chemicals and Environment

描述（由申请人提供）：尽管控制环境暴露的尝试取得了成功，但它们仍然是环境/职业健康方面的一个国际问题。纽约科学院和新泽西州立大学罗格斯分校将于2013年5月29日至31日在纽约科学院联合举办为期2.5天的会议，题为“骨髓生态位、干细胞和白血病：药物、化学物质和环境的影响”，会议将召集来自毒理学和血液学两个不同研究领域的约200名代表，围绕着一个共同的目标——更好地理解、预防和治疗髓系肿瘤。本次会议的主要目标是：(i)提供一个中立的论坛，讨论当前和新兴的骨髓生态位生物学概念，包括健康和白血病造血干细胞的成熟和分化，以及参与骨髓异常发展的环境、化学和遗传因素；通过简短谈话、海报、旅行研究金和折扣登记吸引/展示早期职业、女性和代表性不足的族裔/少数民族调查人员，并提供与高级调查人员互动的机会；向国际社会散发会议记录；（四）促进学术界、临床医生、政府和监管机构以及化学工业之间的合作，促进知识交流，从而成功地将研究成果转化为改进的患者治疗和政策。会议将把骨髓生态位水平的基础科学和毒理学研究与健康受试者和患者的临床发现结合起来。网络活动，早期职业和少数研究者简短会谈，小组讨论和海报会议将为多学科参与者提供互动的机会，这些参与者可能不会在单一的科学会议上互动，包括毒理学家，环境科学家，分子和细胞生物学家，以及检查环境，化学物质和临床治疗对骨髓发育影响的临床研究人员。以及临床血液学家，肿瘤学家，医生和研究人员专门研究白血病，淋巴瘤和其他血液和骨髓疾病。会议上的讨论以及通过在《纽约科学院年鉴》（Annals of New York Academy of Sciences）上的出版物进行的传播将产生全球影响，并最终有助于预防骨髓发育不良、急性髓性白血病和其他骨髓疾病，并有助于开发抗癌疗法，降低治疗引起的继发性癌症的风险。只有通过本次会议设想的跨领域合作研究，我们才能充分了解干细胞在骨髓生态位中发育的机制，以及环境因素对骨髓生态位的危害，并确定降低新疗法对骨髓损伤风险的方法。

DESCRIPTION (provided by applicant): Despite successful attempts to control environmental exposures, they remain an international problem in environmental/occupational health. The New York Academy of Sciences and Rutgers, The State University of New Jersey, will jointly present a 2.5-day conference, The Bone Marrow Niche, Stem Cells, and Leukemia: Impact of Drugs, Chemicals and the Environment, at the New York Academy of Sciences on May 29-31, 2013, convening approximately 200 representatives of two disparate fields of research, toxicology and hematology, around a jointly shared goal - to better understand, prevent, and treat myeloid neoplasms. The main objectives of this conference are to: (i) Provide a neutral forum for discussion of the current and emerging concepts of bone marrow niche biology, including the maturation and differentiation of healthy and leukemogenic hematopoietic stem cells, and the environmental, chemical, and genetic factors involved in the development of myeloid abnormalities; (ii) Attract/showcase early career, female and underrepresented ethnic/racial minority investigators via short talks, posters, travel fellowships, and discounted registration, and provide opportunities to interact with senior investigators; (iii) Disseminate the conference proceedings to the global community; and (iv) Foster collaboration between academia, clinicians, government and regulatory agencies, and the chemical industry to promote a knowledge exchange leading to successful translation of research into improved patient therapies and policy. Conference sessions will combine basic science and toxicology research at the level of the bone marrow niche with clinical findings from healthy subjects and patients. Networking events, early career and minority investigator short talks, panel discussions, and a Poster Session will provide opportunities for interaction among the multidisciplinary participants who may not otherwise interact at a single scientific meeting, including toxicologists, environmental scientists, molecular and cellular biologists, and clinical researchers examining the effects of the environment, chemicals, and clinical therapeutics on bone marrow development, as well as clinical hematologists, oncologists, physicians and researchers that specialize in leukemia, lymphoma, and other disorders of the blood and bone marrow. Discussions originating from the conference and their dissemination via publication in a volume of Annals of the New York Academy of Sciences will have global impact and ultimately aid in the prevention of myelodysplasia, acute myelogenous leukemia and other disorders of the bone marrow, and contribute to the development of anti-cancer therapeutics with reduced risk of therapy-induced secondary cancers. Only through cross-field collaborative research envisioned as a result of this conference can we fully understand the mechanisms by which stem cells develop in, and environmental factors harm, the bone marrow niche, and identify ways in which to reduce the risk of bone marrow damage from new therapeutics.