Developing an HIV Prevention Program for High Risk Couples

描述（由申请人提供）：在这项R34研究中，我们将开发并试点一项针对跨性别女性及其男性主要伴侣的以夫妻为重点的艾滋病毒预防干预措施。在美国，变性女性是感染艾滋病毒的最高风险群体之一，变性女性报告说，她们与主要男性伴侣发生无保护的性行为的频率最高。与变性女性发生性行为的男性最近被确定为艾滋病毒的高危人群。目前还没有基于证据的干预措施来减少跨性别妇女或mstw的艾滋病毒感染。我们提出了一项创新研究，该研究将采用经验支持的以夫妻为中心的艾滋病毒干预原则，以开发一种干预措施，以降低跨性别女性及其男性主要伴侣的艾滋病毒风险。在调整夫妻咨询材料后，我们将在60对由跨性别女性及其男性主要伴侣组成的夫妇中试点测试以夫妻为中心的干预措施。研究结果将为夫妻预防艾滋病干预试验的效果、可行性、可接受性和实施过程提供初步数据。如果这项研究显示出初步的希望，我们将使用这些发现来支持R01应用，在随机对照试验中测试干预效果。

DESCRIPTION (provided by applicant): In this R34 research study we will develop and pilot-test a couples focused HIV prevention intervention addressing transgender women and their male primary partners. In the U.S., transgender women are among the highest-risk groups for HIV infection, and transgender women report most frequently engaging in unprotected sex with their male primary partners. Men who have sex with transgender women (MSTWs) have recently been identified as a high-risk population for HIV. Currently there are no evidence-based interventions to reduce HIV infection in transgender women or MSTWs. We propose an innovative research study that will adapt principles from empirically supported couples-focused HIV interventions in order to develop an intervention to reduce HIV risk in transgender women and their male primary partners. After adapting couples counseling materials, we will pilot test the couples-focused intervention with 60 couples comprising transgender women and their male primary partners. Findings will provide preliminary data on the effects, feasibility, acceptability, and implementation process of a couples HIV prevention intervention trial. If this research shows initial promise, we will use findings to support an R01 application to test intervention efficacy in a randomized controlled trial.