Laboratory Animal Medicine and Translational Research Training for Veterinarians

描述（由申请人提供）：生物医学研究的稳定增长涉及复杂动物模型的利用，导致需要训练有素的实验室动物兽医来管理，指导和提供临床和监管支持。此外，兽医是研究团队的重要成员，因为他们在整体动物生物学，病理学和外科学方面的独特，比较培训。该提案的总体目标是在实验室动物医学和研究方法学方面再培训3名研究生兽医，具体目标是为潜在的职业生涯培养出色的实验室动物兽医 在学术界、工业界和教学界。培训时间为2年临床实验动物医学和1年研究方法学（总共3年培训）。美国华盛顿大学由于其在联邦研究基金中排名第一，（2010年获得资助的公立大学第二名），关联的华盛顿国家灵长类动物研究中心（WaNPRC）和水产和渔业科学学院，大型当地生物技术社区（Amgen Inc，ZymoGenetics Inc，etc），以及在高度合作的环境中成功培训实验室动物兽医的28年悠久历史。该提案的具体目标是：（1）培训兽医科学家，从事生物医学和行为研究中使用的动物的生物学、护理和治疗、检测和预防疾病。我们将通过U.W.利用教学课程和轮换。比较医学系（DCM）和WaNPRC管理的动物设施，U.W.动物福利办公室（OAW），替代医学和职业健康与安全计划，转基因资源，以及当地的生物技术公司提供深入的实验室动物医学培训，由美国实验动物医学学院（ACLAM）认证;（2）培训兽医科学家在生物医学研究方法，重点是涉及小鼠或非人类灵长类动物模型的转化研究。兽医参与者将在DCM或WaNPRC实验室进行基于假设的研究，目的是发表同行评审的手稿，以获得ACLAM委员会考试的资格。研究培训和教学课程将侧重于利用遗传工程小鼠（GEM）和非人灵长类动物在免疫学，传染病，行为，癌症和衰老研究中的转化应用。这些目标将确保U.W.实验室动物医学专业的毕业生都经过严格的培训，成为ACLAM委员会认证;以解决国家的生物医学，行为和临床需求;并作为成功的合作研究科学家。

DESCRIPTION (provided by applicant): The steady growth of biomedical research involving the utilization of complex animal models has resulted in a need for highly trained laboratory animal veterinarians to manage, direct, and provide clinical and regulatory support. In addition, veterinarians are essential members of research teams due to their unique, comparative training in whole-animal biology, pathology, and surgery. The overall goal of this proposal is to train 3 additional post-graduate veterinarians in laboratory animal medicine and research methodology with the specific objective of preparing exceptional lab animal veterinarians for potential careers in academia, industry, and teaching. The duration of training will be 2 years of clinical laborator animal medicine, and 1 year of research methodology (3 years total training). The University of Washington (U.W.) is ideally positioned to accomplish these goals, due to its top-ranking in Federal Research Funding (#2 Funded Public University in 2010), associated Washington National Primate Research Center (WaNPRC) and School of Aquatic and Fishery Sciences, large local biotechnology community (Amgen Inc, ZymoGenetics Inc, etc), and long, 28 year history of successfully training laboratory animal veterinarians in a highly collaborative environment. The Specific Aims of this proposal are: (1) To train veterinary scientists in the biology, care, and treatment, detection, and prevention of disease in animals used in biomedical and behavioral research. We will utilize didactic courses and rotations through the U.W. Department Comparative Medicine (DCM) and WaNPRC- managed animal facilities, U.W. Office of Animal Welfare (OAW), Preventative Medicine and Occupational Health and Safety Programs, Transgenic Resources, and local biotechnology companies to provide in-depth Lab Animal Medicine training certified by the American College of Laboratory Animal Medicine (ACLAM); (2) To train veterinary scientists in biomedical research methodology, with emphasis on translational research involving mice or non-human primate models. Veterinary participants will perform hypothesis-based research in DCM or WaNPRC laboratories, with the goal of publishing a peer-reviewed manuscript to qualify for the ACLAM-board examination. Research training and didactic courses will focus on translational applications of utilizing genetically engineered mice (GEM) and non-human primates in Immunology, Infectious Disease, Behavior, Cancer, and Aging research. These Aims will ensure that U.W. Laboratory Animal Medicine graduates are highly-trained to become ACLAM-board certified; to address the Nation's biomedical, behavioral, and clinical needs; and to serve as successful collaborative research scientists.